In this CBG Isolate guide, you’ll learn more about the potential uses of our CBG concentrate and why GVB Biopharma is one of the world’s premier producers of this niche bulk ingredient. Cannabigerol (CBG) isolate is an ultra-pure cannabinoid extract that contains greater than 98% CBG. While CBG is similar to cannabidiol (CBD) in many ways, CBG is a distinct molecule with its own set of properties. Accordingly, there is a unique market for CBG products. GVB Biopharma’s CBG isolate can also be combined with other cannabinoid extracts to harness a potential form of cannabinoid synergy, called the entourage effect. This effect is the embodiment of the idea that the sum is greater than its parts. In this effect, cannabinoid compounds work together to produce a more beneficial effect than when used alone¹.
Since our ultra-pure CBG is in powdered form, it is easy to add bulk CBG to almost any other product type.
To order samples, or learn more about our CBG Isolate click here
What is CBG Isolate?
This isolate is a type of hemp extract that has been purified so that almost all other substances besides CBG have been eliminated. GVB Biopharma’s CBG isolate routinely tests at ~99% purity, making our CBG preparation one of the purest options on the market.
While other forms of CBG extract possess tiny amounts of CBG from low-yielding hemp plants, GVB Biopharma derives its bulk CBG isolate and CBG Distillate from plants that have been bred to contain high levels of cannabigerol. Not only is deriving CBG from high-CBG producing plants more efficient and environmentally friendly but also requires less processing.
In GVB Biopharma’s isolate, nearly all traces of compounds other than CBG have been removed from the extract. Furthermore, this powdered extract contains non-detectable levels of THC. There is so little of this intoxicating cannabinoid present that even the most advanced testing equipment cannot detect it. Our CBG preparation does not contain detectable levels of CBD, CBN, CBC, or any of the other cannabinoids.
Now that the CBD market is firmly established, consumers are looking to CBG for variety and its unique properties. Whether you choose to combine our CBG isolate with CBD or other stand-alone cannabigerol products, there are many products consumers are learning to associate with CBG.
Why CBG Isolate Matters More Than Ever in 2025
The cannabinoid landscape has evolved dramatically since CBG first entered the market. In 2025, CBG isolate has emerged as a critical ingredient for brands seeking differentiation in an increasingly crowded wellness space.
Market Momentum: The global CBG market has experienced explosive growth, valued at $8.33 billion in 2023 and projected to reach $60.84 billion by 2033, expanding at a CAGR of 22%. As CBD products saturate the market, forward-thinking brands are turning to CBG to offer novel experiences and targeted benefits that CBD alone cannot provide.
Scientific Validation: Recent research from leading institutions has begun to validate what early adopters suspected—CBG offers distinct mechanisms of action that complement other cannabinoids. This scientific backing is driving both consumer confidence and regulatory clarity.
Manufacturing Maturity: Unlike the early days of CBG production, where purity and consistency were concerns, 2025 has brought sophisticated extraction technologies and high-CBG hemp genetics. Producers like GVB Biopharma now routinely achieve 98-99% purity with reliable, scalable processes—making CBG isolate a practical choice for serious formulators.
Regulatory Clarity: As the hemp industry matures, compliance frameworks have become more defined. Brands launching products in 2025 benefit from clearer testing standards, THC thresholds, and labeling requirements, reducing the regulatory uncertainty that plagued earlier entrants.
How CBG Isolate Is Made: Extraction to Crystallization
Step 1: High-CBG Hemp Cultivation
Unlike traditional CBD-dominant hemp, GVB Biopharma uses genetics specifically bred for elevated CBG content. This genetic advantage reduces processing requirements and environmental impact.
Step 2: Primary Extraction
CO₂ or Ethanol Extraction: Fresh hemp biomass undergoes supercritical CO₂ or ethanol extraction to pull cannabinoids, terpenes, and plant compounds from the plant material. GVB Biopharma’s extraction parameters are optimized specifically for CBG retention, ensuring maximum yield without degradation.
The result is a crude hemp extract containing CBG alongside other cannabinoids, lipids, waxes, and chlorophyll.
Step 3: Winterization
The crude extract is mixed with ethanol and frozen to sub-zero temperatures (-20°C to -40°C). This process causes fats, waxes, and lipids to precipitate out of solution, where they can be filtered away. Winterization produces a cleaner extract ready for further refinement.
Step 4: Distillation
Short-Path or Wiped-Film Distillation: The winterized extract undergoes vacuum distillation to separate cannabinoids by boiling point. CBG is isolated from remaining plant compounds, minor cannabinoids, and any residual solvents. Multiple distillation passes increase purity progressively.
At this stage, the product is CBG distillate—a viscous, amber liquid typically 80-90% pure.
Step 5: Crystallization and Isolation
Recrystallization Process: To achieve 98-99% purity, the distillate undergoes controlled crystallization. The CBG distillate is dissolved in a solvent (often pentane or heptane), then slowly cooled under precise conditions. Pure CBG molecules form crystals while impurities remain in solution.
The crystals are separated, washed, and dried under vacuum to remove all traces of solvent, yielding pure, white CBG isolate powder.
Step 6: Final Testing and Certification
Every batch undergoes comprehensive third-party testing for:
– Cannabinoid potency (confirming >98% CBG)
– THC content (non-detect levels)
– Residual solvents (below FDA limits)
– Heavy metals, pesticides, and microbials
Only batches meeting GVB Biopharma’s strict standards receive Certificates of Analysis (COAs) and are released for sale.
Why This Matters: This multi-stage purification process is what separates pharmaceutical-grade isolate from inferior products. Brands that skip steps or rush production end up with lower purity, residual contaminants, or inconsistent cannabinoid profiles—all of which compromise product safety and efficacy.
What US Brands Must Know About CBG Isolate Compliance in 2025
Navigating the regulatory environment for hemp-derived cannabinoids requires vigilance. Here’s what brands must understand to stay compliant.
Federal Framework: The 2018 Farm Bill and Beyond
The 2018 Farm Bill legalized hemp-derived cannabinoids containing less than 0.3% delta-9 THC on a dry weight basis. CBG isolate, when derived from compliant hemp and containing non-detectable THC, falls under this federal definition.
Critical Requirement: All CBG isolate must be accompanied by third-party COAs proving THC levels below the federal threshold. Brands are responsible for verifying supplier documentation and maintaining chain-of-custody records.
State-Level Considerations
While federally compliant, hemp-derived CBG faces varying state regulations:
– States with additional hemp restrictions: Idaho, South Dakota (consult legal counsel)
– States requiring hemp handler licenses: Oregon, California, Colorado (supplier must hold permits)
– States with unique testing requirements: California (Prop 65 compliance for heavy metals)
Action Item: Before launching products, confirm your CBG isolate supplier can provide state-specific compliance documentation for your target markets.
FDA Position on Cannabinoids in 2025
As of 2025, the FDA has not approved CBD or other cannabinoids (including CBG) for use in food, beverages, or dietary supplements. However, the agency has not broadly enforced against hemp-derived cannabinoid products.
Risk Management Strategies:
1. Avoid disease claims (therapeutic, diagnostic, or treatment claims trigger FDA scrutiny)
2. Use structure/function language carefully (e.g., “supports wellness” not “treats anxiety”)
3. Maintain robust adverse event monitoring systems
4. Ensure all marketing materials are compliant with FTC guidelines
Third-Party Testing Requirements
All CBG isolate sold to brands should include COAs testing for:
– Cannabinoid potency panel (CBG, CBD, CBN, THC, etc.)
– Residual solvents (ethanol, pentane, heptane, etc.)
– Heavy metals (lead, arsenic, mercury, cadmium)
– Pesticides (state-specific panels)
– Microbials (total yeast/mold, E. coli, Salmonella)
GVB Biopharma Standard: Every batch undergoes ISO-accredited third-party testing with full panel results available before shipment. This eliminates guesswork and ensures brands receive only compliant material.
Labeling and Marketing Compliance
Required Label Elements:
– Accurate cannabinoid content per serving
– “Hemp-derived” or “contains hemp extract” disclosure
– Batch/lot numbers for traceability
– Manufacturer/distributor information
– Appropriate disclaimers
Prohibited Claims: Avoid any language suggesting CBG treats, cures, or prevents disease. Focus on general wellness benefits backed by structure/function claim standards.
Supply Chain Transparency
In 2025, brands are increasingly liable for supplier misconduct. Choosing a transparent supplier like GVB Biopharma—with full seed-to-sale traceability, batch tracking, and documentation—protects your brand from regulatory and reputational risk.
Bottom Line: Regulatory compliance isn’t optional—it’s the foundation of sustainable brand growth. Partner with suppliers who treat compliance as seriously as you do.
Which product types are ideal for CBG isolate?
Our CBG preparation can be used in any product where CBD isolate is currently used. For instance, this powder can be added to tinctures, capsules, and other orally ingested products. CBG is also becoming popular in topical products due to growing awareness of this cannabinoid’s potential for treating pruritus (itchy, dry skin) and inflammatory skin diseases³.
Like other purified cannabinoid products, CBG is easy to work with. Since the isolate is ~99%-pure, it is easy to calculate dosages when formulating CBG products. Our CBG isolate is ideal in products that wish to include the particular benefits of cannabigerol. This bulk ingredient adds value to CBD products due to its synergy with other cannabinoids.
Combining CBD and CBG easily creates products that provide cannabinoid synergy. Purified CBD products generally target consumers who do not wish to consume any THC. However, these products do not provide any entourage effect. By adding CBG, these consumers can enjoy the improved synergy of the combined cannabinoids without any THC in their product⁴.
Why is GVB Biopharma the best source of bulk CBG isolate?
GVB Biopharma rises above the competition by producing this product from only high-CBG hemp plants. Since our CBG comes from hemp flowers that are already high in CBG, less agricultural space is used and less plant material is wasted, resulting in better, environmentally friendly, less expensive, bulk ingredients.
Our CBG isolate is incredibly pure and sustainably derived, providing better reliability and effectiveness than competing bulk CBG ingredients. In addition, our strict oversight at every stage of production ensures that our bulk CBG isolate meets or exceeds the highest regulatory and compliance standards.
Currently, GVB Biopharma is one of the world’s most popular producers of wholesale purified CBG extract. We owe our success to rigorous, multi-stage testing, total transparency, and state-of-the-art production processes. Our clients trust us for timely and reliable CBG delivery. In the following section, we’ll discuss each of the factors that set GVB Biopharma apart from our competitors.
Testing and Quality
All GVB Biopharma products are tested multiple times throughout the production process. First, we test the seeds used to grow our hemp crops to ensure that they meet our purity and quality standards. As our hemp grows and matures, we make regular quality control assessments to ensure that no pesticides or other toxins contaminate our crops.
We test our newly harvested hemp to make sure that our previous quality control measures were accurate. We test the crude extract, derived from our hemp, to ensure that no residual solvents are present. Once THC and the other unnecessary components in this crude extract have been removed, we test our proprietary CBG isolate to ensure that it contains the proper concentration of cannabigerol.
Customers may buy our CBG and manufacture their own products or allow us to infuse CBG into white-label products that they can bring to market. If you select either of these services, we will test all products for purity and potency prior to shipment.
Very few cannabinoid producers undertake such stringent measures to ensure that their CBG is of high-potency and free of contaminants (like heavy metals). Lab reports are readily available for both our bulk CBG isolate and our pre-made products that contain this CBG concentrate.
Certified Producer
At GVB Biopharma, we proactively seek any and all certifications that may be relevant to our business operations. We were one of the first hemp facilities in Oregon to receive food-grade certification. We also work with local fire marshals to ensure that all of our facilities are compliant with current fire safety standards.
Most importantly, GVB Oregon holds an ISO 9001:2015 certification and NSF International’s Good Manufacturing Practice Registration for dietary supplements. NSF International is a leading certification agency that verifies a manufacturing facility has the proper methods, equipment, facilities, and controls in place to produce dietary supplement products in accordance with the pertinent U.S. Food and Drug Administration’s regulations.
GVB also recently received a Handling certification from California Certified Organic Farmers (CCOF) and has started producing Certified Active Pharmaceutical Ingredients (API).
Each of our certifications demonstrates our commitment to maintaining the highest possible levels of quality control and quality assurance. Furthermore, we observe all OSHA workplace safety standards and fire code requirements to ensure no hazardous contaminants are present.
Third-party validation is necessary to confirm the purity of our products and the integrity of our organization. Every certification ensures that GVB Biopharma is one of the nation’s most reputable suppliers of CBD isolate, other cannabinoid extracts, and finished products.
Fast Shipping
GVB Biopharma has locations throughout the United States and in the UK. Currently, we are in the process of opening a mainland European office. GVB is also one of the first cannabinoid producers to have a presence in South America, with our Bogata, Colombia location.
Due to the array of facilities we have established around the world, we offer fast shipping services to more nations than nearly all of our competitors. Once you have placed an order with us, you can normally expect fulfillment within 24 hours. We can also use expedited shipping services to make sure your products arrive even faster.
With full tracking for every order, you will never have to wonder about the location of your purchase. Our customer service team is also available if you have any questions about your order.
Easy Reordering
At GVB Biopharma, we impose a 1-kilo minimum on all of our bulk wholesale orders. From your first order, our knowledgeable customer service staff will be standing by to answer all your questions and resolve any possible issues.
You will be supplied with a dedicated customer service contact and we will keep in touch to make sure your order meets your satisfaction. When it’s time to reorder, simply get in touch with your designated GVB Biopharma associate or contact us directly at support@gvbbiopharma.com.
Common CBG isolate FAQs
1. What is CBG Isolate?
It is CBG in its purest form—a pure white powder almost exclusively composed of CBG. At over 98% pure CBG, it has the highest potency of any CBG extract.
2. How do I use CBG isolate?
It can be used on its own for a CBG-centric finished product or added to an existing product formulation to augment its complete cannabinoid profile.
3. CBG Isolate Dosage
Because this CBG extract is nearly pure CBG, it is very easy to accurately calculate its final concentration in any finished product. By consulting your raw material COA for the total amount of CBG, you can easily determine the amount of CBG isolate needed for your finished product formulation.
4. CBG Powder vs Liquid
You can purchase CBG in powder (isolate) or liquid (distillate) form from a reputable supplier. Depending upon the activities you want your finished product to promote or the base of your finished product formulation, you can choose either preparation. Discuss your finished product formulation with your supplier and ask for their advice. They should be able to help you make the best decision.
5. Where can I buy CBG
It’s important to choose a reliable supplier when purchasing any raw cannabinoid product. You can purchase samples of CBG isolate or CBG distillate right here on our website. If you would like to purchase a larger quantity, please call for our wholesale pricing.
6. What can I do with CBG isolate?
This CBG product is a highly versatile raw material with dozens of different potential uses. Like all cannabinoid isolates, our CBG comes in a simple powderized form that is easy to add to essentially any oil-based product formulation.
Due to its high purity, it’s easy to add the right amount of CBG isolate to your product formulation. However, please do not try to use CBG isolate on its own. Its extraordinary purity and potency require mixing this powdered cannabinoid isolate with other ingredients prior to use.
7. Can CBG isolate be used topically?
No, it is not possible to use this CBG preparation topically without first combining it with other ingredients. Simply by itself, this molecularly homogenous cannabinoid powder does not pass through the layers of your skin, causing any CBG applied topically to be wasted.
If you want to use our concentrated CBG topically, you will need to thoroughly mix it with a topical formulation that is skin-penetrating and effective. It’s possible to do so just by mixing CBG isolate with a standard lotion. However, using a product, formulated specifically to be compatible with CBG, is better.
8. How much CBG isolate should I use?
There are no official guidelines for safe dosing of CBG, so it is impossible to definitively say exactly how much pure CBG you should either ingest or mix into products. Based on anecdotal testimony, doses of 25-50mg CBG appear to be standard. Most CBG products contain around 500-2000mg CBG overall.
9. What are the benefits of CBG isolate powder?
The primary benefit of CBG isolate powder — the same as any other cannabinoid isolate powder — is its versatility and accessibility.
At the same time, you can add CBG isolate to practically anything. With this cannabinoid increasingly in demand as an addition to CBD, it’s convenient that CBG isolate powder easily mixes with existing product formulations.
10. What are the negative effects of CBG?
Just as is the case with CBD, CBG very rarely has significant side effects. In some individuals, both cannabinoids can cause symptoms typical of the cannabis plant, including dry mouth, dizziness, sleepiness, or nausea.
It also appears that CBG may have side effects related to its beneficial effect profile. In comparison to CBD, the most commonly reported adverse effects of CBG are digestive discomfort or disruption.
11. Is CBG stronger than CBD?
In terms of experienced effects, most users would agree that CBG is somewhat more intense than CBD. If not necessarily more potent, CBG is simply different from the CBD. It may engage your endocannabinoid receptors in ways CBD does not. Where CBD is relaxing, CBG is energizing. Where CBD makes you feel mellow, CBG makes you engaged. Arguably, the psychoactive effects of CBG may be more intense than those of CBD, but it’s an undeniable fact that neither cannabinoid gets you “high.”
12. What is CBG isolate used for?
This Isolate is generally used to make very simple product formulations or as an addition to existing formulations that contain CBD or another cannabinoid. Compared to forms of CBG extract that contain a full or fuller complement of minor cannabinoids and terpenes, CBG isolate may have fewer applications.
It’s purity and specific actions make CBG isolate attractive for a wide range of different products. CBG isolate alone is often added to tinctures, capsules, and gummies, and, when combined with other cannabinoids, it is commonly used in topicals.
13. Where can I buy CBG crystals in bulk?
The best place to buy purified CBG isolate extract online is GVB Biopharma. With its network of global offices and the most sophisticated extraction and production facilities in the industry, GVB Biopharma is an international leader in the minor cannabinoid market, specializing in a wide range of CBG extracts. Contact us today to bring CBG isolate into your product line.
Add CBG isolate to your product lineup today
A few short years ago, hardly anybody even knew that CBG existed. Today, there is a growing demand for this popular cannabinoid in product types as diverse as topical creams, facial serums, and edible gummies. An increasing number of brands are also starting to add CBG isolate to existing product formulations to boost their potency and beneficial effects.
If you decide to use our bulk CBG isolate, remember that GVB Biopharma is a full-service bulk ingredient and white-label manufacturer. We are always standing by to help you reach your goals. With our unparalleled focus on transparency, quality, and customer service, GVB Biopharma can help you successfully incorporate CBG isolate into your brand.
References
- 1. Ferber, S. G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., … & Weller, A. (2020). The “entourage effect”: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders. Current Neuropharmacology, 18(2), 87-96.Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/
- 2. Mishchenko, S., Laiko, I., & Kyrychenko, H. (2021). Breeding of industrial hemp with a high content of cannabigerol by the case of ‘Vik 2020’cultivar. Plant Varieties Studying and Protection, 17(2), 105-112. Retrieved from https://pubag.nal.usda.gov/catalog/7849447
- 3. Eagleston, L. R., Kalani, N. K., Patel, R. R., Flaten, H. K., Dunnick, C. A., & Dellavalle, R. P. (2018). Cannabinoids in dermatology: A scoping review. Dermatology Online Journal, 24(6). Retrieved from https://escholarship.org/content/qt7pn8c0sb/qt7pn8c0sb.pdf
- 4. Anokwuru, C. P., Makolo, F. L., Sandasi, M., Tankeu, S. Y., Elisha, I. L., Agoni, C., … & Viljoen, A. (2022). Cannabigerol: a bibliometric overview and review of research on an important phytocannabinoid. Phytochemistry Reviews, 1-25. Retrieved from https://link.springer.com/article/10.1007/s11101-021-09794-w
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