GVB’s Approach

How Can We Rationally Assess the Utility of Phytocannabinoids in Human Health?

GVB Has Created a Unique, Integrated System That Makes This Possible

Gene editing (or genome editing) utilizes an array of tools and techniques, such as CRISPR technology, to alter an organism’s DNA in a precise and targeted way. Gene editing can modify specific points within the organism’s own DNA, affecting only the altered DNA sequence. This differs from traditional genetic modification (GM), where internal DNA changes or DNA from an unrelated species are introduced into the genome of an organism, often in a non-targeted way.

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Step 1

The end-use need is determined by the GVB team and the R&D group. They decide together what needs to change.

Step 2

Through sequencing and mapping, we utilize the DNA to determine the target section.

Step 3

A guide for precision (RNA strand) is created and attached to an enzyme. The RNA then finds the target section of the DNA while the enzyme works like a pair of scissors to cut the DNA.

Step 4

From there, the edited DNA section can naturally heal itself with minor changes altering the gene function, or it can heal itself with a section missing making the gene inoperable.

New fields in biology, such as molecular genetics, metabolomics, and bioinformatics, empower and guide our designs for new hemp/cannabis strains. We can then use various genetic engineering techniques, such as DNA sequencing, molecular breeding, and gene/genome editing, to create the changes we desire. These modern techniques allow us to determine the specific DNA coding sequences that hemp/cannabis uses to produce cannabinoids or terpenes of interest, to edit these sequences in a precise manner, and to quickly measure the results of these changes. For example, we can now manipulate hemp/cannabis to increase levels of therapeutic cannabinoids (such as cannabidiol) or modulate the relative amounts of volatile fragrant terpenes to suit consumer preferences.

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GVB has optimized phytocannabinoid production from seed to shelf. They offer scalable production, extraction, and packaging of valuable cannabinoids for bulk and specialty markets. GVB hemp/cannabis research is centered on developing strains with enhanced agronomics and disease/pest resistance that can be grown indoors and out. We have been able to develop hemp with elevated CBD, along with negligible THC. GVB’s R&D collaborations enhance these efforts by accelerating conventional breeding, introducing new breeding techniques (such as gene editing and molecular breeding), and employing human cell-based assay systems to help define cannabinoid potency.

FAQs

Agronomy refers to the science and technology involved in cultivating and using plants for food, fuel, fiber, chemicals, recreation, or land conservation. Agronomy has come to include research in plant genetics, plant physiology, meteorology, and soil science.

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