Author: GVB Biopharma

As the hemp industry continues to expand at an unprecedented rate, CBD brands everywhere need hemp manufacturers they can trust to provide excellent bulk products at reasonable prices. Accountability is more important in the CBD industry than ever, requiring many brands to choose a reliable international CBD manufacturer. In this guide, learn how to find the best hemp manufacturers that supply products in your area, and discover if it’s as important as it seems to partner with an industry-leading manufacturer.

The importance of finding a reliable CBD manufacturer

The CBD industry has reached previously undreamed-of levels of annual sales volume and global legitimacy. Along with any successful venture, comes those seeking to prey on new or inexperienced companies trying to make their way within a rapidly shifting landscape.

While the newfound size and scope of the global CBD industry might lead some to believe the market’s wild west days are over, there are still plenty of hemp manufacturers out there that will try to supply you with sub-par products at sky-high prices. As a result, it’s more important than ever that you find a CBD producer you can hold accountable—whether it’s by maintaining a constant channel of communication or touring the manufacturer’s production facilities in person.

Factors to consider when selecting a hemp manufacturer near me

Before you start searching for the right CBD manufacturer supplying your area, it’s important to know what to look for. Here are a few of the most critical factors you should consider when determining if a hemp white-label supplier is a good fit: 

Vertical integration

If a hemp company offers vertical integration, that means they control every aspect of the production process from seed to sale. Vertical integration eliminates quality-reducing mistakes that can occur when products are handed off between companies during manufacturing, and it proves a hemp manufacturer has the capability to handle all of its own processes.

Extraction method

Some hemp extraction methods are acceptable while others aren’t. While both CO2 and ethanol extraction can produce 100% clean and solvent-free end products, BHO and similar extraction methods invariably result in inferior or even dangerous concentrates.

Certifications

The hemp industry no longer exists in a vacuum—CBD manufacturers must now abide by the same standards of certification that ensure product quality in other consumer goods industries. Reliable hemp manufacturers actively seek out opportunities for certification instead of complying only when regulators come knocking.

How do I find a hemp supplier? 7 simple steps

Now that you know what to look for, let’s cover the method you should use as you select an ideal hemp supplier that provides bulk products in your local area:

1. Perform a web search

It might not be glamorous, but the best way to start the process of finding your ideal hemp supplier is to simply perform a few Google searches. Not only will this help you start building out your list of potential companies to work with, but it will also show which companies have enough search authority to show up for relevant queries.

2. Evaluate the capabilities and reliability of various companies

As you scroll through search results, evaluate potential companies based on the criteria we listed above. Which hemp manufacturers that service your area are vertically integrated? Which ones are properly certified, and which extraction methods do they use?

3. Make a list of potential options

By this point, you should have come across 5-10 bulk hemp suppliers that at least somewhat match your criteria. Note the names of every company that might be a good fit, and find the contact information for each.

4. Reach out to the companies on your list

By phone, email, or contact form, reach out to each CBD private labeler that shows promise. You may be able to start weeding out ineligible companies at this point based on how easy each manufacturer makes this step.

5. Narrow down your options based on the responses you receive

You can learn a lot based on how hemp producers respond to business inquiries. Cross off any companies on your list that don’t courteously respond to your inquiry in a timely manner.

6. Follow up with companies on your shortlist

For those companies that do respond quickly and informatively, continue the interaction to narrow down your options to a single manufacturer. In the end, only one company will offer the right combination of customer communication, relevant certification, product customization, and pricing you are looking for.

7. Pick a winner

Based on what you’ve learned so far about each company on your shortlist, you now have everything you need to pick the right hemp supplier for your needs. Discard all other options, and start negotiating seriously with a single lucky company.

Which CBD manufacturing company is the most reliable?

As you get to know us from your initial discovery call onward, you’ll come to recognize that GVB Biopharma is one of the most reliable, responsible, and client-centered international white-label and bulk ingredient manufacturers in the industry. Offering a unique trifecta of abundant certifications, vertical integration, and endless customizability, GVB services multiple continents and ships bulk cannabinoid products to addresses in all 50 states. Some of the unique benefits of working with GVB include:

– Full vertical integration

– CCOF organic certification

– Water-soluble & rare cannabinoid products

– Rigorous, multi-stage lab testing

– Total transparency (tours provided)

– Competitive Pricing

– Impeccable communication

The bottom line: Is it important for your hemp manufacturer to be local?

In reality, you don’t need your hemp supplier to be headquartered in your area to offer all the benefits of a local company. With the wonders of modern-day eCommerce, it’s possible to receive just as much assurance regarding a hemp producer’s reliability whether they’re headquartered in your own backyard or halfway across the country.

By limiting your options to companies based in your local area, you might miss out on the enhanced benefits a larger and more-qualified hemp producer could offer. Wherever you might be located, GVB Biopharma will go above and beyond to make you feel like you’re only minutes away. Our business development representatives are available to answer any questions that come up.

CBD manufacturers near me FAQ

Still, need some help finding the right CBD manufacturer that supplies your area? Check below for answers to common related questions:

Do private-label CBD manufacturers near me always offer the best value?

No, limiting your options to white-label CBD producers in your local area will actually reduce the potential value you can get out of a bulk hemp business deal. There’s no guarantee that a hemp producer runs its business efficiently and offers high-quality products just because it happens to be located near you. To get the most value possible, expand your pool to companies that service the entire nation.

Which questions should I ask a CBD manufacturer near me?

To make sure that a bulk CBD manufacturer servicing your area offers the most value and best products, start by asking if they practice vertical integration and seek out every available certification. From there, inquire about available product types and opportunities for customization. It’s also important to discuss shipping times, finished product formulations, and any other factors that might impact the manufacturing and fulfillment of your products.

What is the best hemp product on the market?

CBD tinctures continue to reign supreme as the most popular types of hemp products available online. Tinctures have evolved considerably in recent years, though, and they now often include abundant minor cannabinoids and niche types of hemp extract like THC-Free CBN Distillate.

What are the top-selling CBD products in 2022?

If you want to make sure your CBD products sell-through at rapid rates, it’s important to offer industry stand-bys like CBD tinctures. According to Statista, however, CBD topicals have shown the most rapid growth over recent years, and consumers are also keenly interested in the potential benefits of CBD capsules and gummies.

How do I find the best CBD products?

One of the best ways to find out which company makes the best CBD products is to check customer reviews. Customers leave reviews online for both CBD brands and bulk CBD producers—to find reviews for a brand, check the brand’s website, and for bulk CBD producer reviews, take a look at the company’s Google Maps profile.

How much does wholesale CBD cost?

The price of wholesale CBD can vary considerably depending on the type of CBD in question, the quantity you order, and the company you choose to work with. To learn more about our bulk pricing, contact us here.

How do I start selling CBD products?

To start selling CBD products, you’ll need to begin by finding the right bulk CBD supplier. Brands that work with bulk suppliers have the considerable advantage of not needing to invest in expensive extraction equipment or source raw materials. The right supplier can also serve as a trusted source of information on how to succeed in the rapidly changing hemp industry.

What are the top hemp companies?

Over the last few years, the names of the world’s top hemp companies have shifted from name brands to bulk suppliers, which now control the largest share of the CBD and wider cannabinoid market. These companies have proven to brands and consumers alike that their superior production processes result in reliable, high-quality products that are nonetheless offered for lower prices due to vastly improved efficiency.

What is the most profitable CBD company?

Perhaps counterintuitively, the most profitable CBD companies are not usually those that make the most money in the short term. Dozens of CBD companies emerged in the wake of the 2018 Farm Bill, for instance, that made enormous profits amid a chaotic industry environment. Those companies are no longer around, though, while the CBD companies that took the slow but sure route have now raked in quarter after quarter of recurring profits.

What is the most profitable form of hemp?

If you want to exchange each acre of hemp for the most cash possible, you’ll want to make sure it’s smokable grade. Buds that are smokable-grade often net two or three times the price per pound of non-smokable hemp, but they’re also a lot harder to grow. Ultimately, there isn’t a lot of profit to be made in hemp for small-time operators, making it prudent to work with larger companies that have already cornered the market.

Are hemp stores profitable?

Hemp specialty stores can be profitable in certain regional markets, but they’re inevitably outperformed by online competitors. The best way to launch a successful online hemp store these days is to begin by making a relationship with a qualified CBD white labeler.

CBD (cannabidiol) isolate is one of the simplest types of hemp cannabinoid extracts—but it’s also one of the most versatile raw materials at your disposal. Despite being rendered down to 99%+ pure CBD molecules, quality varies significantly among different manufacturers of bulk CBD isolate products, making it necessary to learn as much as possible about this type of extract before you choose a bulk supplier.

In this guide, learn how CBD isolate is made, and discover the factors that separate reliable, trustworthy CBD isolate manufacturers from companies that are not worthy of your business. Along the way, you’ll find answers to other questions you might (and should) be asking as you find the best CBD isolate manufacturer for your brand’s needs.

What is CBD Isolate?

CBD isolate is a powdered substance that consists almost entirely of pure cannabidiol molecules. All other natural components (such as terpenes, THC, or flavonoids) of hemp extract have been removed, leaving only CBD behind. As a result, CBD isolate naturally takes on a purified crystalline form, making it very different in appearance compared to less-processed forms of hemp concentrate. CBD isolate is one of the easiest types of CBD extracts to produce, but an expert touch is nonetheless required to achieve desirable results.

What is CBD isolate made out of?

CBD isolate consists almost entirely of pure CBD molecules. Any other components left behind are only present in trace amounts and usually cannot be detected without comprehensive lab testing. What this means for your brand is that CBD isolate does not contain any added components. It is simply the purest form of cannabidiol available on the market.

What are the benefits of CBD isolate?

CBD isolate captures the acclaimed benefits of this non-intoxicating cannabinoid in a convenient, easy-to-use form.¹ The powder does not contain any traces of THC or other hemp substances aside from CBD. Yes, other forms of CBD extract can also be THC-free seemingly causing CBD isolate to lose its monopoly on this particular benefit.

The fact remains, though, that CBD isolate is remarkably easy to work with, making this type of extract an excellent choice for newbies and veteran CBD brands alike. CBD isolate’s powdered form eliminates messes on the production line, and simplifies measuring exact doses of CBD.

What are the features of CBD isolate?

CBD isolate has roughly standard features regardless of the manufacturer. The main differentiator between bulk CBD isolate options is quality instead of potency. As long as it was manufactured correctly, CBD isolate should be a white, powdery substance that contains more than 99% cannabinoids.

How is CBD Isolate manufactured?

CBD isolate is produced by extracting the oils from mature hemp flowers and then removing all components aside from CBD molecules².

The process used to isolate CBD from the other hemp flower components varies depending on the manufacturer. Keep in mind that GVB utilizes a highly refined forced crystallization process. Whichever process is used, the end result should be high-potency CBD extract consisting of 99%+ pure cannabidiol.

Can I buy CBD isolate in bulk?

Yes, bulk CBD isolate is widely available on the internet, and it’s one of the most cost-efficient and versatile types of CBD extract you can buy. Compared to other types of CBD extracts, CBD isolate often costs less and, due to its dry, powdered form is easier to package and ship. As you make your selection, prioritize CBD isolate manufacturers with an overabundance of certifications and a focus on total transparency.

What is a CBD isolate powder manufacturer?

A CBD isolate manufacturer is a company that uses CBD-rich hemp flowers to produce CBD isolate in bulk. As it is one of the easiest forms of CBD extract to make, the bar to entry for CBD isolate manufacturing is lower than it is for other extracts. Resultantly, there’s a significant gulf between the best CBD isolate manufacturer on the internet and the worst.

Qualities of a reliable CBD isolate manufacturing company

How do you tell a good CBD isolate manufacturer from a bad one? You’ll probably need to get on the phone and talk with a sales representative to get the full story. Remember that there are a few categories in which a CBD isolate manufacturer absolutely must get high marks in order to be qualified as your supplier:

High-tech processes

The processes you use to make CBD isolate can have a profound impact on the end result. Using inferior production processes can result in contaminants remaining in CBD³ isolate after the refinement process is complete. Even if concentrations under 1%, any presence of contaminants in CBD isolate can pose health and safety concerns.

Multiple cannabinoids available

If a CBD isolate manufacturer also offers other cannabinoids in isolated form, that’s a sign they’ve achieved enough success to branch out into additional ventures. Beware of companies that only offer CBD isolate—that may be an indication a company is small and uses inferior processes, not that they’ve chosen to focus on one type of extract.

Comprehensive lab testing

It isn’t enough to simply test CBD isolate once the finished product is ready for sale. A skilled CBD manufacturer will test the materials that can be refined to CBD isolate at every stage of the production process as opposed once the process is finished.

Across-the-board certifications

For too long, hemp producers operated in the dark. Nowadays, there’s no reason to run a hemp production business as an illicit venture. The right CBD isolate manufacturer will be certified just as much as any other producer of fine products. GVB Biopharma proactively seeks out every available opportunity for certification to provide our customers with utmost peace of mind.

How do you find the best CBD isolate manufacturers?

Finding a CBD isolate manufacturer isn’t like buying a consumer product on the internet. The product description is only the beginning of the conversation—asking questions is essential and should be encouraged by the manufacturer you’re questioning. Even if you think you’ve found a good match, keep asking questions until you know for sure that the manufacturer you’ve contacted will be able to fulfill your exact needs.

How do I get started with CBD isolate?

To start offering premium hemp products containing CBD isolate, contact GVB Biopharma customer care today. A representative will walk you through the process and ask questions to ensure they understand your goals.

If you find that you’re ready to proceed, it’s possible to place your first order the very same day. Otherwise, we’ll keep communications open and provide you with all the time you need to make a final decision you’re comfortable with.

CBD isolate manufacturer FAQ

To finish up, we’ll answer some common questions regarding CBD isolate manufacturers and what they do:

1. Do CBD isolate manufacturers also make other products?

Yes, most CBD isolate manufacturers also make other hemp extracts, and in fact, offering multiple types of extracts is one of the hallmarks of a reliable and trustworthy CBD isolate manufacturer. The right CBD isolate producer doesn’t necessarily have to produce the most extracts of any company on the internet, but offering more than just a handful of products indicates that a company has the production facilities necessary to produce high-quality extracts.

2. How much is a kilo of CBD isolate?

Prices for a kilo of CBD isolate vary considerably depending on the quality of the extract and the manufacturer in question. In addition, pricing generally goes down quite a bit when you order multiple kilos of CBD isolate at a time. As you select the right CBD manufacturer, try to find a reasonable bulk price that is somewhere in the middle of the range listed above.

3. How much is CBD isolate per gram?

Purchased on a per-gram basis, CBD isolate cost can be relatively costly. Purchased in bulk, the price point drops astronomically—if you get the right deal. Keep in mind, though, that the cheapest CBD isolate may not be the best CBD isolate for your brand. While you shouldn’t overpay for this abundant and simple type of CBD extract, it’s just as important to avoid purchasing contaminated or low-quality isolate.

4. Which is better: CBD isolate or full-spectrum?

When it comes to the differences between isolated and full-spectrum CBD extracts, it isn’t a question of better or worse. These two types of concentrated CBD are simply different, and they may be applicable and widely different situations.

CBD isolate, for instance, is ideal for simple products that are designed to offer the benefits of CBD and nothing more. Full spectrum CBD, on the other hand, is more suited for organic or all-natural products that capture the potential of the entourage effect⁴.

What’s more, you can even add CBD isolate to other types of hemp extracts to formulate products that contain plenty of CBD but also other cannabinoids and beneficial compounds. The sky’s the limit when it comes to the potential applications of CBD extracts.

5. How pure is CBD isolate?

CBD isolate is generally at least 99% pure. Some CBD isolate manufacturers can boost this purity to upwards of 99.8%, but achieving the highest-possible CBD purity levels is not the primary concern of most hemp extract producers. Instead, it’s far more important to ensure that the remaining tiny percentage of the extract that is not CBD is not composed of contaminants or dangerous substances.

6. What are CBD isolate machine manufacturers?

The term “CBD isolate machine manufacturer” refers to a company that manufactures machines used to produce CBD isolate. Some CBD isolate manufacturers purchase their processing equipment from other companies while others develop their own CBD isolate extraction and purification processes in-house. As you move through the process of finding a CBD isolate manufacturer, make sure you aren’t buying a machine used to make CBD isolate instead.

7. What is the ICNI name for CBD isolate?

Within the system of categorization known as the International Nomenclature of Cosmetic Ingredients (ICNI), isolated cannabidiol extract is known as “Cannabidiol.” Technically, this name only applies to isolated CBD, and products containing more than just homogenous cannabidiol should be labeled as such.

It may occasionally have practical utility, but the ICNI is mainly used to help regulators keep track of ingredients commonly used in cosmetics. Outside the world of topically applied substances, ICNI definitions are entirely irrelevant.

8. At what temperature does CBD isolate degrade?

Studies show that CBD begins to degrade when exposed to heat exceeding 40° F and fully degrades at temperatures exceeding 160° F. CBD isolate products should be kept in conditions where temperatures are lower than 40° C (100° F) to prevent premature degradation. In fact, cannabinoid extracts (even isolates) tend to do best in cool, dry conditions not exceeding 25° C (75° F) for ideal preservation.

9. Does CBD isolate need to be heat-activated?

No, CBD isolate products do not generally need to be heat-activated (decarboxylated) prior to use. The vast majority of CBD isolate products are provided in a pre-decarboxylated state, which means they are ready to be added to product formulations with no need for heat activation.

If this is not the case, the product will be labeled as CBDa instead of CBD to indicate that it contains the carboxylic acid precursor to CBD rather than the cannabinoid’s decarboxylated form. Compared to CBD, CBDa products are few and far between, so it is very unlikely that any CBD isolate product you come across needs to be heat-activated before use.

10. Why is CBD isolate white?

CBD isolate is white since CBD naturally takes on a colorless, crystalline form when purified and separated from all other substances. The presence of any hues other than pure white, in fact, can indicate that CBD isolate contains contaminants. It is ideal for CBD isolate to be as white as snow, and a white appearance does not indicate that there is anything wrong with your CBD isolate.

References

1. 1. Cather, J. C., & Cather, J. C. (2020, July). Cannabidiol primer for healthcare professionals. In Baylor University Medical Center Proceedings (Vol. 33, No. 3, pp. 376-379). Taylor & Francis. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340472/
2. 2. Teräsvalli, H. (2020). Extraction and purification of cannabidiol. Retrieved from https://lutpub.lut.fi/bitstream/handle/10024/161311/Kandidaatintyo_Heini_Terasvalli.pdf?sequence=1&isAllowed=y
3. 3. Evans, D. G. (2020). Medical fraud, mislabeling, contamination: all common in CBD products. Missouri Medicine, 117(5), 394. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723146/
4. 4. Ferber, S. G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., … & Weller, A. (2020). The “entourage effect”: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders. Current Neuropharmacology, 18(2), 87-96. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324885/

Looking for a reliable CBD gummy manufacturer? With so many options available, it can be helpful to learn more about your options before you narrow down on a final choice.

Offering full vertical integration, above-and-beyond compliance, end-to-end lab testing, and more, GVB Biopharma is the world’s preferred manufacturer of bulk CBD gummies. In this guide, find out what CBD gummies are, why consumers want them, and how to find the best bulk supplier for your CBD gummy needs.

What are CBD gummies?

A CBD gummy is a sweet, sometimes sour, chewy, fruit-flavored edible product that contains high concentrations of cannabidiol (CBD). Non-intoxicating yet highly beneficial, CBD has gained massive popularity worldwide over the last decade, and gummies are among the most popular types of CBD products.

What are CBD gummies made out of?

CBD gummies generally consist of a thickener, like pectin, and a sweetener along with various ingredients added for coloring or flavoring. The right bulk CBD gummy manufacturer will be happy to work with you to develop the exact type of custom CBD gummy formulation that’s right for your needs.

What are the benefits of CBD gummies?

Consumers like CBD gummies because they’re tasty and convenient while still potently providing the benefits of CBD. Popular among individuals who dislike the inherently bitter taste of hemp, CBD gummies cover up any unwanted flavors while adding a layer of carefree fun to the CBD experience.

How are CBD gummies manufactured?

Compared to some bulk CBD products, the CBD gummy manufacturing process is relatively simple. First, a formulation is decided upon that will fulfill all the client’s needs. Then, the formulation is created in a heated, liquid state.

Next, the liquid CBD gummy formulation is poured into molds, where it then cools and solidifies into a stable shape. Finally, the hardened gummies are placed inside airtight containers, and labels are applied prior to shipment.

What are the features of CBD gummies?

CBD gummies vary considerably based on a few categories. They can contain a variety of different concentrations of CBD, for instance, and they can include full-spectrum, broad-spectrum, or even isolate CBD.

In addition, the flavor, sugar content, and types of flavoring and sweetening ingredients used can fluctuate wildly among bulk CBD gummy options. Some companies focus on all-natural, organic ingredients, but don’t assume that all CBD gummy companies treat the health and safety of your customers with the same degree of seriousness.

Can I buy CBD gummies in bulk?

Yes, CBD gummies are available to purchase in bulk online. Worthwhile CBD white labellers will be able to supply either pre-formulated CBD gummies in a variety of options or offer to work with you to develop custom formulations. Do your research to make sure you’re getting the highest-quality white label CBD gummies for the lowest price.

What is a CBD private label gummy manufacturer?

A private label CBD gummy manufacturer is a company that produces CBD gummies in bulk and then puts your brand’s label on the bottle. For many CBD companies, white labeling is the easiest and most cost-effective option while also ensuring a higher caliber of quality than small companies can usually offer on their own. As a result, working with a CBD gummy private labeler is quickly becoming the default option for CBD brands around the world.

Hallmarks of a reliable CBD gummy manufacturer

What sets trustworthy CBD gummy manufacturers apart from the crowd? There are five features you should look for in prospective CBD private labelers above all others, and we’ll discuss each of these decision-making variables below:

Full vertical integration

Offering full vertical integration means a CBD gummy manufacturer controls every aspect of the production process from beginning to end. Full vertical integration is a sign that a company has achieved a level of self-sufficiency that prevents products from becoming cobbled-together messes.

High-quality ingredients

Even if consumers won’t know the difference, ingredient quality matters. If a CBD gummy manufacturer cuts corners in its ingredients, that means they probably aren’t being entirely honest with their clients, either.

Custom formulations available

You might not want to be stuck with the products everyone else is offering, which is why offering customized formulations is so important when you’re selecting the right CBD gummy manufacturer. If a hemp white labeller refuses to accommodate your customization requests, try a different company.

Comprehensive lab testing

It’s normal for hemp white labelers to do their own lab testing—that’s part of full vertical integration. If this testing isn’t rigorous or consistent, however, problems are bound to emerge. As a general rule, CBD private labellers should test their products at every stage of production: seed, harvest, extraction, and final formulation.

Across-the-board certification

There’s nothing shady about the hemp industry anymore, and responsible CBD gummy white labelers go out of their way to offer full transparency by acquiring as many relevant certifications as possible. The more certifications a CBD bulk producer has, the more reliable they are likely to be.

How do you choose the right private label CBD gummy manufacturer?

When you’re choosing the right manufacturer to help your CBD gummy dreams take flight, there’s no reason to rush into things. Take the time necessary to fully vet the company before you make a final decision—write down a list of questions to ask your sales rep, research the company’s reputation online, and don’t be afraid to ask some tough questions as you make absolutely sure you’ve found a good match. In the end, making a decision that results in a mutually beneficial, long-term business relationship is more important than getting your new CBD gummies in your hands as soon as possible.

How do I get started with CBD gummies?

To get started with your very own line of high-quality CBD gummies, contact GVB Biopharma customer care today. A representative will walk you through our process and answer any initial questions you may have.

Depending on the circumstances, you could arrive at an agreement and begin production the next day. If you’d prefer to take your time, though, that’s certainly an option as well. Your customer care representative will provide you with everything you need to approach the process at your own pace.

CBD gummy manufacturer FAQ

To finish up, let’s answer a few common questions related to white labeling CBD gummies:

1. What is a CBD gummy contract manufacturer?

“CBD gummy contract manufacturer” means the same thing as “CBD gummy white labeler” or “CBD gummy private labeller.” In the world of bulk product sales, the term “contract manufacturer” is sometimes used to describe a company that produces products for another business. The right CBD gummy contract manufacturer will listen carefully to your needs and deliver a product that fully exceeds your expectations.

2. Is small-scale gummy-making equipment worth it?

Usually, it’s not worth it for a small-or-medium business to invest in its own gummy-manufacturing equipment. The types of gummy machines that fit within the budget of a small business don’t provide the high-quality results today’s competitive market demands, and investing in high-end equipment is not economically feasible. As a result, it’s best to rely on a private labeller to make your gummies for you.

3. How do I find a CBD gummy manufacturer in California?

GVB Biopharma services CBD brands based in California, the rest of the United States, and various locations around the world. As a California-based business, it is not necessary to purchase bulk CBD gummies from a company that is also based in the Golden State, and expanding your options to the rest of the country results in a wider pool of potential suppliers.

Competition is one of the main drivers of quality regardless of the industry in question. Limiting yourself to CBD gummy manufacturers based in your home state will lead to reduced quality and diminished customer satisfaction.

4. How do I find a CBD gummy manufacturer in Colorado?

Despite being one of the biggest hemp-producing states in the nation, Colorado is home to surprisingly few reliable CBD gummy manufacturers. Thankfully, neither state nor federal law prohibit Colorado businesses from buying bulk CBD gummies from producers in other states, allowing Colorado CBD companies to choose from among the wide variety of hemp white labellers present on the internet.

5. Where do I buy organic CBD gummies private label?

GVB Biopharma can work with you to ensure your CBD gummies meet any safety or sustainability requirements you may require. Despite increased consumer interest in all-natural and organic products, surprisingly few CBD white labellers offer hemp gummies that contain only organic ingredients. GVB Biopharma, however, offers complete customization throughout the CBD gummy development and formulation process.

If there’s an ingredient you’d like replaced or upgraded, all it takes is a single phone call. With a wider selection of ingredients and more reliable processes than any competitors have to offer, GVB Biopharma is the be-all, end-all of customized CBD gummy white label solutions.

6. Are CBD gummies FDA-approved?

No, as of April 2022, the FDA has not approved any CBD gummy products. Keep in mind that the FDA approves products, not substances. At present, the only FDA-approved CBD product is Epidiolex, a prescription drug intended to treat epilepsy and a small group of related conditions.

Revision of the federal government’s stance on CBD products has been long-expected but may take even longer to fully materialize. In the interim, the 2018 Farm Bill provides all the legal protection necessary for CBD white labelers to produce gummy products and for hemp brands to sell them to consumers.

7. Are CBD gummies legal in all states?

The 2018 Farm Bill stipulates that natural Cannabis sativa products containing less than 0.3% THC are industrial hemp, not marijuana. As a result, interstate CBD commerce is common, and operators generally only raise the ire of the federal government when they make illegal medical claims.

Certain states or municipalities may have established local rules related to CBD commerce, however. Make sure to check in with relevant authorities in your area to determine the precise legality of CBD gummies and related hemp products.

8. How do you manufacture CBD gummies?

CBD gummies are usually manufactured very similarly to the way that other types of gummies are manufactured. The main difference, of course, is the inclusion of CBD — and sometimes other cannabinoids, as in the case of full-spectrum and broad-spectrum extracts.

Also, since CBD is generally considered to be a natural health product, it’s somewhat more common for CBD gummies to be organic and all-natural than is the case for gummies that do not contain CBD. There’s no guarantee that a gummy will be all-natural, though, just because it contains CBD.

9. What are the different types of CBD gummies?

The two major kinds of CBD gummies are full-spectrum CBD gummies and THC-free CBD gummies. There are two different kinds of THC-free CBD gummies, though — those that contain isolate CBD, and those that contain broad-spectrum CBD.

It’s also important to take into consideration the immense differences that can exist between individual CBD gummy products. You could say, for instance, that there is a “conventional type” of CBD gummy that might contain artificial sweeteners, colorings, etc., as well as a “natural type” that only contains all-natural or organic ingredients.

10. What should I look for in CBD gummies?

CBD gummies should, ideally, contain all-natural ingredients and come with lab tests proving their safety and purity. Manufacturers of CBD gummies should operate fully certified facilities complete with state-of-the-art equipment, and their customer service representatives should be knowledgeable about their gummy offerings.

11. Which CBD gummies are the strongest?

The strongest CBD gummies contain full-spectrum extract and at least 25mg CBD per gummy. The maximum amount of CBD that is usually desirable in a gummy is 50mg, but full-spectrum extract boosts the benefits of CBD, making less count for more.

The list of cannabinoids catching the eye of the international scientific community grows every day. Recently, cannabicyclol (CBL) has risen to the forefront due to its unique structure and intriguing therapeutic properties. Perhaps a sought-after missing link in the cannabinoid chain, CBL has the potential to perfect the entourage effect and vastly expand our understanding of what cannabis has to offer.

In this informational overview, learn what CBL is, catch up on the latest CBL research, and find out how CBL compares to other cannabinoids. Then, learn what CBL products are available, and begin your preparations for the coming cannabicyclol wave.

What is CBL?

Cannabicyclol is a rare cannabinoid that naturally occurs when cannabichromene (CBC) oxidizes. In this way, cannabicyclol has the same relationship to CBC that cannabinol (CBN) has to THC—both cannabinoids are entirely natural but only appear when another cannabinoid oxidizes.

A variety of factors can cause CBC to oxidize into CBL. Heat, age, and UV light can all trigger the process, but in most cases, CBL is artificially oxidized in a lab. This does nothing to contaminate the end product but simply speeds along the conversion process.

What kind of research is being done on CBL?

Cannabicyclol is one of the least-researched cannabinoids. A full pharmacological evaluation has yet to be conducted, meaning we still don’t have any direct evidence regarding whether CBL might offer unique benefits compared to other cannabinoids.

While this means there’s a lot we still can’t say about CBL, it also makes this cannabinoid a hotbed of possibilities. It’s anyone’s guess what we might learn about CBL in the future, but here’s what we know so far:

1. CBL was first discovered by Raphael Mechoulam’s Israeli team of cannabis researchers¹ in 1966

2. Considerable chemical experimentation² has been conducted upon cannabicyclol since, but little attention has been paid to its potential medicinal uses

3. In 2008, cannabicyclol was detected in a 2,700-year-old cannabis sample³ unearthed in China

4. Recent consumer interest in CBL will likely spur further research—including a comprehensive pharmacological evaluation

Who is the target audience for CBL?

Once products containing cannabicyclol become available, they will most likely appeal to adventurous consumers who are already accustomed to cannabinoids and want to try something new. We don’t know which potential benefits CBL may offer at this point, making it difficult to speculate on this cannabinoid’s eventual appeal with any greater specificity.

What are the effects of CBL?

At the moment, we’re largely in the dark regarding how CBL affects the human body and might alter your mind. Since this cannabinoid is a derivative of CBC, however, it is likely to be non-intoxicating. CBC has thoroughly non-intoxicating effects, and if the relationship between THC and CBN is any example, cannabinoids that emerge via oxidation usually have weaker effects than their origin substances.

What are the benefits of CBL?

Until the pharmacological effects of CBL are fully understood, we only have enough data to speculate on one of this cannabinoid’s potential benefits: its contribution to the entourage effect. The ultimate cannabis experience seems to be hidden away in some as-yet-undiscovered combination of cannabinoids, terpenes, and flavonoids. The more cannabinoids we have to work with, the more likely we’ll discover new ways to expand the benefits of the entourage effect⁴.

While definitive conclusions about the benefits of cannabicyclol (CBL) are still pending due to limited research, existing data allows us to explore its potential contributions to the entourage effect—a phenomenon where multiple cannabinoids and terpenes work synergistically to enhance each other’s therapeutic effects. CBL’s unique chemical structure suggests that it may interact with various receptors in the endocannabinoid system, potentially modulating pain, inflammation, and mood more effectively when combined with other cannabinoids.

Moreover, preliminary insights from chemical experimentation indicate that CBL might possess anti-inflammatory and antioxidant properties, which could make it beneficial in managing chronic inflammation and oxidative stress-related conditions. Its non-intoxicating nature also implies that CBL could offer therapeutic benefits without the psychoactive effects associated with THC, making it an attractive option for individuals seeking relief without impairment.

In addition to its potential therapeutic roles, CBL’s stability and resistance to oxidation compared to other cannabinoids like THC and CBD could make it a valuable component in long-lasting cannabis products. This stability might enhance the shelf-life and efficacy of cannabis formulations, ensuring consistent therapeutic outcomes over time.

As research progresses, we may uncover more specific benefits of CBL, such as its role in neuroprotection, mood regulation, and possibly even cancer inhibition. The ongoing exploration of CBL will likely contribute to a more nuanced understanding of how various cannabinoids can be optimized in medicinal and wellness applications, ultimately enriching the cannabis industry’s offerings and expanding the therapeutic possibilities available to consumers.

CBL vs. CBD vs. CBG vs. CBT vs. THC

How does CBL compare to other cannabinoids in terms of its effects, benefits, and regulatory status? Let’s find out:

CBL vs. CBD

Other than both being non-intoxicating, CBL doesn’t appear to bear that much resemblance to CBD. The two hemp cannabinoids come from considerably different lineages, after all: CBD converts from CBGa via CBDa while CBL takes the long way around as a metabolite of CBC. We’ll know more about how CBD and CBL square up once we’ve acquired significant data regarding CBL’s potential benefits.

CBL vs. CBG

Likewise, the relationship between CBG and CBL doesn’t seem all that close. As a direct metabolite of CBGa, CBG is only one degree of separation away from the cannabinoid “source” while CBL is a few more degrees removed. The benefits of CBG and CBL may line up in ways that will only become apparent once we’ve learned more about CBL’s effects in the human body.

CBL vs. CBT

CBL and CBT are more related than most cannabinoids. Both substances are derived from CBC: While CBL emerges from CBC due to oxidation, CBT comes into existence when CBC undergoes an enzymatic reaction. As is the case with CBL, future research will reveal the potential benefits of CBT, but the ever-increasing popularity of cannabinoids all-but ensures future research into both substances.

CBL vs. THC

CBL isn’t very similar to THC. These two substances emerge during the maturation of cannabis flower in very different ways, and the effects of CBL and THC are unlikely to line up in any major categories.  While we still do not know about CBL’s effects, it’s very unlikely this cannabinoid induces any degree of intoxication.

Which cannabinoids compliment CBL products?

Integrating cannabicyclol (CBL) into cannabinoid products opens up a plethora of possibilities for creating unique and effective formulations. While the market for CBL-infused products is still emerging, strategic pairing with other cannabinoids can enhance the overall efficacy and appeal of these products. Specifically, CBL is anticipated to pair exceptionally well with cannabichromene (CBC) and cannabigerol (CBG), two cannabinoids that also contribute to the entourage effect.

CBC (Cannabichromene):

In addition to the entourage effect, CBC and CBL combine to offer another type of synergy. CBC itself is relatively new to the cannabinoid market, and pairing CBC with CBL helps consumers familiarize themselves with this entire family of new hemp compounds. Plus, CBL will benefit from the increased legitimacy CBC offers as a cannabinoid that has been on the market for a while already.

CBG (Cannabigerol):

CBD has done so much to change the world, but in the end, it’s only one cannabinoid. This leader of the hemp movement has learned to share space with CBG, which is increasingly viewed as CBD’s equal across the board. Pairing CBL with CBG preserves CBL’s novel mystique while also offering benefits you won’t find in CBD products.

Best white label products to infuse with CBL

Once bulk CBL becomes available, which types of products will be best to infuse with the unprecedented benefits of this rare cannabinoid? We think capsules, tinctures, and gummies will lead the way as the emerging CBL market evolves.

1. White label CBL capsules

Capsules are familiar enough to make even brand-new cannabinoids like CBL seem approachable. Plus, capsules are inherently convenient, and hemp consumers have already gotten used to taking their daily doses of cannabinoids in capsule form. It’s simple to combine multiple cannabinoids inside capsules, leaving room for CBL products that target the entourage effect.

2. Wholesale CBL tinctures

Some hemp consumers will be fans of capsules, and others will prefer tinctures. In fact, some cannabinoid users like to have both on hand—tinctures allow more pinpoint dosing but are less convenient while capsules offer unique value thanks to their dose-and-forget simplicity. Crafting a CBL tincture will provide you with opportunities to put your brand’s unique stamp on your products in the form of a singular blend of additional ingredients.

3. Bulk CBL gummies

Gummies are taking the cannabinoid market by storm, and the distinctive appeal of hemp gummies perfectly complements the brand-newness of CBL. Formulable in sweet or sour variations, gummies lend a friendly zest to using hemp that accentuates CBL’s never-before-experienced benefits.

How to succeed with CBL

First, CBD proved the general market was ready for cannabis-derived products as long as they didn’t contain enough THC to get you high. Then, CBG proved the world of hemp isn’t limited to just CBD. Over the intervening years, additional non-intoxicating cannabinoids like CBN, CBC, CBDv, and CBGa emerged, further expanding the hemp playing field and revealing the foundations of a much-larger global cannabinoid economy than anyone ever anticipated.

Consider the ongoing emergence of cannabinoids like CBL and CBT as the “fourth wave” of the hemp economy. By now, there are so many cannabinoids available that consumers have overcome their skepticism and will more readily accept each new hemp cannabinoid as it appears. The mystery of CBL is its greatest attribute at the moment, but as we learn more about what this cannabinoid has to offer, CBL will find its rightful place within a pantheon of hemp compounds increasingly viewed as legitimate medicines.

Though it might not be available yet, start planning for your products to contain CBL sooner rather than later. In the near future, the brand that’s best able to blend the benefits of multiple cannabinoids into a single product will command the most consumer attention, so emerging cannabinoids like CBL shouldn’t be exempt from your expectations for the bright future of the global hemp industry.

Cannabicyclol cannabinoid FAQs

1. Is CBL better than CBD?

We don’t know enough about CBL yet to say how it might compare to CBD. On the other hand, we now know enough about CBD to conclude that it might have at least some therapeutic potential against some conditions, resulting in — among other things — a prescription drug being made using CBD. As more CBL research comes in over the next few years, we might find sufficient evidence to start comparing it to other cannabinoids.

2. Is CBL the same as CBT?

No, CBL and CBT are different cannabinoids even though they’re often associated with each other. There’s solid grounds for this association since both cannabinoids are related to CBC, but it appears that CBL and CBT have unique properties justifying conducting research into each cannabinoid in greater detail.

3. Is CBL psychoactive?

There is no indication that CBL is psychoactive in the sense of being intoxicating, but all cannabinoids are psychoactive to some degree — even CBD. With that said, CBL is related to CBC, which is considered to be non-intoxicating. As a result, the logical likelihood that CBL will be found to have intoxicating attributes is very low.

4. What does CBL do to your brain?

We don’t know enough about CBL yet to speculate on the potential effects it might have on the human brain. Studies into CBC, though (the source compound of CBL), suggest that this cannabinoid might interact strongly with the TRP receptors throughout your body, which are involved in inflammation and inflammatory pain. CBL should be researched in more detail both to confirm or deny these purported effects of CBC and also to determine if they might be stronger when offered in the form of this close derivative.

Sources

1. 1. Hashish. Its Chemistry and Pharmacology. (1966). Annals of Internal Medicine, 64(1), 227. https://doi.org/10.7326/0003-4819-64-1-227_7
2. 2. Vree, T., Breimer, D., van Ginneken, C., & van Rossum, J. (1972). Identification of cannabicyclol with a pentyl or propyl side-chain by means of combined as chromatography—mass spectrometry. Journal of Chromatography A, 74(1), 124–127. https://doi.org/10.1016/s0021-9673(01)94980-5
3. 3. Russo, E. B., Jiang, H. E., Li, X., Sutton, A., Carboni, A., del Bianco, F., Mandolino, G., Potter, D. J., Zhao, Y. X., Bera, S., Zhang, Y. B., Lü, E. G., Ferguson, D. K., Hueber, F., Zhao, L. C., Liu, C. J., Wang, Y. F., & Li, C. S. (2008). Phytochemical and genetic analyses of ancient cannabis from Central Asia. Journal of Experimental Botany, 59(15), 4171–4182. https://doi.org/10.1093/jxb/ern260
4. 4. Russo, E. B. (2019). The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Frontiers in Plant Science, 9. https://doi.org/10.3389/fpls.2018.01969

Dubbed “the plant of the thousand and one molecules¹,” cannabis always provides us with new opportunities for discovery. Although the existence of CBT has been known for some time, the potential uses of this minor cannabinoid have only recently been explored.

With the latest advancements in cannabis science, it’s easy to imagine a world in which even the rarest cannabinoids are readily available. In this guide, you will learn what CBT is, and why you should be keeping track of the rapid evolution of CBT in the cannabis world.

What is CBTC?

Cannabicitran (CBT) is a rare—yet naturally occurring—hemp cannabinoid that is also known as CBT-C. It was first synthesized in 1971 by Crombie and Ponsford² At the time, they named it citrylidene-cannabis. In 1974, Bercht et al³ were the first to detect naturally occurring Cannabicitran in Cannabis sativa.. CBT has been a primary target of research and development operations since 2019.⁴ In fact, industry leaders are currently in the early stages of developing a variety of CBT-C products that could revolutionize the hemp industry by unlocking the unique benefits of this highly promising cannabinoid.

We’re still learning about all the different ways this cannabinoid might affect the human body. Like CBD and CBG, however, CBT appears to be non-intoxicating, and its potential benefits are significant enough to be worthy of growing attention from the international scientific community.

What kind of research is being done on CBT-C?

Although research on CBT-C is still in its early stages, a recent study offers valuable insights into its chirality and pharmacological profile. In 2011, Japanese researchers isolated a substance chemically identical to CBTC⁵ from Rhododendron anthopogonoides, a plant extensively used in Traditional Chinese Medicine (TCM). It could be argued that TCM practitioners have been using CBT for centuries, lending legitimacy to modern CBTC research.

Then, an exhaustive 2018 study published in Natural Product Communications⁶ provided more background regarding the origins of CBTC in cannabis. An unstable cannabinoid easily altered by enzymatic reactions, cannabichromene (CBC)⁷, serves as the immediate chemical precursor of CBTC in cannabis, not CBGa. This information raises new questions, regarding the metabolism of cannabis flowers as they mature.

The scientific community is eagerly looking forward to the results of research into CBT-C. This rare cannabinoid’s unique benefits are just now being uncovered, and what we’ve learned so far has the potential to revolutionize the global cannabis industry.

Who is the target audience for CBT-C?

Right now, CBT-C most appeals to adventurous cannabinoid consumers who always want to try the next best thing. It is still somewhat of a scientific mystery how this cannabinoid affects the human body and mind at present, but fans of CBD and CBG are endlessly eager to try new, non-psychoactive cannabinoids that may impart unique benefits not offered by other hemp compounds.

What are the effects of CBT-C?

Based on limited anecdotal testimony, CBT appears to have non-intoxicating effects that largely resemble the effects offered by CBD, CBG, or any other hemp cannabinoid that doesn’t cause intoxication. As one of the most obscure and least-used hemp substances, there isn’t enough anecdotal evidence yet to draw any firm conclusions regarding how CBT will affect individuals on a case-by-case basis.

What are the benefits of CBT?

In the cannabis industry, CBTC is sometimes used as an anti-crystallization ingredient since it helps compounds like CBD resist reverting to their natural crystalline states. The chemical structure of CBTC has the same relationship to CBD as CBD has to THC, making it useful in identifying cannabinoids in a sample.

A 1984 study⁸  revealed the impact of CBTC on glaucoma, potentially making this cannabinoid a non-intoxicating cannabis option for glaucoma patients currently using THC. Given CBTC’s unique chemical synthesis within the cannabis flower, we can expect to be surprised regarding what we learn about this cannabinoid’s unique benefits over the coming years.

CBTC Cannabinoid Comparisons

To further elucidate the unique benefits of CBTC, let’s compare it to a few other cannabinoids:

CBTC vs. CBD

In molecular structure, CBTC bears a close resemblance to CBD. The two cannabinoids also appear to have similar effects, making CBD and CBTC an ideal pair, especially given CBD’s ongoing popularity.

CBTC vs. CBG

As a fellow non-intoxicating cannabinoid, CBTC and CBG (cannabigerol) are more similar than they are different. CBG is the “parent molecule” from which all the most popular cannabis compounds are made. However, CBT is a much more extensively modified cannabinoid than its parent, CBG.

CBTC vs. CBL

Based on what little we know already, CBTC and cannabicyclol (CBL) appear to be quite similar. They’re both derivatives of CBC and they’re both non-intoxicating. While CBTC emerges via natural enzymatic processes in cannabis, CBL comes into existence when CBC oxidizes.

CBTC vs. THC

CBTC and THC aren’t very similar. THC is one of the few cannabinoids to cause intoxicating effects, a trait CBTC doesn’t seem to share. From a regulatory perspective, the legal status of THC and CBTC are also quite different. THC remains a Schedule I drug, while CBTC simply falls under the unregulated industrial hemp category of cannabis products.

Which cannabinoids complement CBTC?

When CBTC becomes available, it will initially be challenging for products containing this novel cannabinoid to gain traction, unless it’s paired with a substance that people are already familiar with. To this end, we suggest combining CBTC with either CBD or CBC: CBD to take the well-traveled route and CBC for a more experimental perspective.

CBD

The gold standard of hemp cannabinoids, CBD, is now as trusted as any over-the-counter medicine or natural remedy. As such, it’s the ideal cannabinoid to pair with CBTC—especially since CBD and CBTC appear to offer similar effects. It’s the most popular cannabinoid on the market, so CBD is available in the widest array of bulk ingredient types.

CBC

CBC is just as ideal of a match for CBTC as CBD but for different reasons. CBD and CBTC are chemically related. However, CBTC and CBC share even more similarities. CBC offers the allure of a new cannabinoid that is, nonetheless, more familiar and approachable than CBTC. Like CBTC, CBC is non-intoxicating.

Best White Label Products To Infuse With CBTC

When will bulk CBTC products become available on the market? Three particular product types jump out as ideal matches for the unique benefits of CBTC:

1. Wholesale CBTC tinctures

Tinctures are the trusted standby of the hemp industry. Consumers are already used to taking tinctures and they rely on them to deliver the benefits of any cannabinoid quickly and effectively.

Tinctures are easily formulable with myriad different botanical ingredients and oils. It’s easy to make a tincture into a unique “business card” consumers can use to identify your brand. What better way to make your brand noticeable than by incorporating a new, exciting cannabinoid!

2. Bulk CBTC capsules

Since the dawn of the modern hemp industry, capsules have served as the default alternative for hemp consumers who don’t want to taste their cannabinoids. Bypassing the sublingual route makes encapsulated products not quite as bioavailable as tinctures. Nonetheless, it’s possible to formulate capsules with just as wide an array of ingredients as tinctures, without the need for flavoring. Capsules make CBT-C more approachable to consumers who are adventurous enough to try a new substance but want to avoid the inherent trickiness of tinctures.

3. White-label CBT-C gummies

They aren’t quite as carb-free as capsules or tinctures, yet gummies are certainly the tastiest types of hemp products you can infuse with CBT-C or any other cannabinoid. Making daily dosing with cannabinoids easy and delicious, gummies are the most fun, approachable type of hemp product. These features may help to reduce the level of hesitation consumers experience when trying a new cannabinoid, like CBT-C.

Preparing for the CBTC wave

CBT-C is hardly the only cannabinoid waiting in the wings. Up until the last decade, research into cannabis was haphazard and mainly carried out by the same teams of isolated Japanese and Israeli researchers. Now that cannabis is increasingly legitimized around the globe, international cannabinoid research efforts have become more cohesive. We’re starting to get some of the first definitive results, regarding the effects of the cannabis plant and the hundreds of distinct compounds it contains.

Alongside CBT-C, related cannabinoids like CBC and CBL are also rising to the forefront of the hemp industry. If this all seems like too much for consumers to keep track of right now, think back to the status of CBD circa 2010. At that point, nobody could have predicted this then-obscure hemp compound would become a household name within less than a decade.

The consumer market simply needs time to adjust to new trends and entrepreneurs have always benefited by preparing for these surges in sentiment before they occur. It’s never too early to start educating consumers, regarding the oncoming CBT-C wave. By offering plentiful, related cannabinoids like CBC, you can give your customers a taste of what to expect when CBT-C products become available.

Cannabicitran FAQs

1. What is CBTC distillate?

Cannabicitran distillate consists of isolated CBT-C combined with a base of hemp distillate. It may contain small concentrations of other cannabinoids, including THC. Distillates also usually include relatively high levels of terpenes and flavonoids that may contribute to the entourage effect.

Even though all available CBT-C has been made in a lab, this cannabinoid looks just like any other when it is provided in distillate form. Generally, CBT-C distillate is honey-like in both color and texture, and it has a light floral aroma.

2. CBT-C vs. CBN?

Though they are both cannabinoids, CBT-C and CBN have practically nothing in common. While CBT-C is a very rare cannabinoid that is hardly ever found in cannabis, CBN is a natural oxidant of THC, so it’s found everywhere. Furthermore, we can’t identify any ways in which the effects of CBN and CBT-C might line up since both cannabinoids have hardly received their fair share of academic attention.

3. What is the difference between H4CBD and CBT-C?

The primary difference between CBT-C and H4CBD is their origin: While CBT-C is rare but naturally occurring, H4CBD can only be made in a lab. These cannabinoids are actually quite similar in terms of what we know about them — both H4CBD and CBT-C remain largely mysterious to scientists, though new research is underway. You’ll also face roughly the same level of difficulty, attempting to find a reliable source of either rare cannabinoid.

4. What are the benefits of CBT-C?

At this stage, it’s truly impossible to say much about the potential therapeutic benefits of CBT-C because this cannabinoid has hardly been researched. This rare cannabinoid appears to share one of CBD’s main benefits: it is non-intoxicating. At this time, there’s no reason to believe it’s any more toxic than other natural cannabinoids.

In its isolated form, CBT-C is as easy to mix into products as any other type of cannabinoid isolate. If anecdotal reports are to be believed, this rare cousin of CBT-C may even have unique medicinal benefits to offer. With so few sources of CBT-C on the market, it can be hard to pin down a reliable supply of this very new — and very rare — hemp substance.

Sources

1. 1. Andre, C. M., Hausman, J. F., & Guerriero, G. (2016). Cannabis sativa: The Plant of the Thousand and One Molecules. Frontiers in Plant Science, 7. https://doi.org/10.3389/fpls.2016.00019
2. 2. Bercht, C., Lousberg, R. J., Küppers, F. J., & Salemink, C. A. (1974). Cannabicitran: A new naturally occurring tetracyclic diether from lebanese Cannabis sativa. Phytochemistry, 13(3), 619–621. https://doi.org/10.1016/s0031-9422(00)91362-1
3. 3. (2019, December 9). GVB Biopharma Begins Research on CBT (Cannabicitran), Unexplored Cannabinoid [Press release]. https://www.biospace.com/article/releases/gvb-biopharma-begins-research-on-cbt-cannabicitran-unexplored-cannabinoid/
4. 4. Iwata, N., & Kitanaka, S. (2011). New Cannabinoid-Like Chromane and Chromene Derivatives from Rhododendron anthopogonoides. Chemical and Pharmaceutical Bulletin, 59(11), 1409–1412. https://doi.org/10.1248/cpb.59.1409
5. 5. Pollastro, F., Caprioglio, D., del Prete, D., Rogati, F., Minassi, A., Taglialatela-Scafati, O., Munoz, E., & Appendino, G. (2018). Cannabichromene. Natural Product Communications, 13(9), 1934578X1801300. https://doi.org/10.1177/1934578×1801300922
6. 6. Elsohly, M. A., Harland, E. C., Benigni, D. A., & Waller, C. W. (1984). Cannabinoids in glaucoma II: The effect of different cannabinoids on intraocular pressure of the rabbit. Current Eye Research, 3(6), 841–850. https://doi.org/10.3109/02713688409000797
7. 7. Elsohly, M. A., Harland, E. C., Benigni, D. A., & Waller, C. W. (1984). Cannabinoids in glaucoma II: The effect of different cannabinoids on intraocular pressure of the rabbit. Current Eye Research, 3(6), 841–850. https://doi.org/10.3109/02713688409000797

Since CBN is gaining popularity faster than almost any other cannabinoid, it’s time to compare two of the most common types of CBN extracts: distillate and isolate. Each form of CBN has its unique advantages, but one type of extract might be more ideal for your particular purposes.

In this guide, we’ll start by making sure you’re familiar with the basics regarding CBN. Then, we’ll briefly define CBN distillate and isolate before diving into a more detailed comparison.

What is CBN?

Cannabinol (CBN) is a natural cannabinoid that’s considered a metabolite of THC. While THC has strong psychoactive effects, however, CBN won’t get you high. In this way, cannabinol is more similar to CBD or CBG regardless of its origins.

CBN is produced from THC due to oxidation – a natural process when THC ages or is exposed to light or heat. While CBN naturally appears when THC oxidizes, it’s also possible to convert CBN from CBD or other hemp cannabinoids. As a result, CBN is now widely sold online.

What are the benefits of CBN?

As one of the least-studied cannabinoids, the benefits of CBN are not yet fully understood. Extremely dated and limited research¹ tentatively indicates CBN should be further researched in the context of sleep-promotion, but modern research into this cannabinoid has focused more on its potential pain-relief² and neuroprotective³ effects. Regardless of its individual benefits, CBN may boost the intensity of the entourage effect⁴ when included in products alongside other hemp cannabinoids. Remember that the entourage effect occurs when cannabinoids work together synergistically to enhance the effects of each other.

How do you use CBN in products?

While research is sill being conducted about the possible sleep-promotion effects of CBN, the general public seems convinced that CBN shows promise as a sleep aid, leading to a heightening popularity of CBN in sleep-promoting products. Awareness has also spread to some degree regarding research into CBN as an analgesic. However, this cannabinoid is mainly desirable as an accompaniment to other hemp compounds due to its entourage effect.

While the individual benefits of CBN require an expert touch to convey, CBD is now a household name, and many CBD consumers are aware of the entourage effect. As a result, the value of any CBD product is likely boosted in the eyes of the consumer if CBN is also included on the label.

What is CBN extract?

CBN extract is derived from a cannabinoid-rich hemp flower that predominantly contains the cannabinoid CBN. This type of bulk hemp ingredient is available in multiple forms, most notably distillate and isolate. Their potency ranges from 70–97% total cannabinoids, and each extract can be used in a wide variety of products.

What is CBN distillate?

CBN distillate is a distilled cannabinoid extract that contains high concentrations of CBN. While CBN distillate is more purified than a crude extract, it still retains the minor cannabinoids, terpenes, and other beneficial substances naturally present in hemp flowers. This attribute makes CBN distillate highly desirable for products like tinctures, gummies, and vape cartridges.

CBN distillate usually has a honey-like appearance and consistency, and it can offer CBN potencies as high as 80%. Some forms of CBN distillate contain trace THC, yet it can also be refined to remove all detectable levels.

What is CBN isolate?

CBN isolate consists almost entirely of pure cannabinol molecules. Offering 97%+ chemical purity, CBN isolate is ideal for formulating into a wide variety of products  even if it is not especially usable in its raw form.

Where this isolated product truly shines is in its ideal suitability for combination with other cannabinoid extracts. CBN isolate makes it easy to infuse any new or existing products with the unique and intriguing benefits of CBN.

CBN distillate vs. CBN isolate

Now that you understand CBN distillate and isolate, it’s time to compare these hemp extracts in more detail. We’ll pit CBN isolate and CBN distillate against each other in eight categories, helping you decide which extract suits your products.

Effects

Because the extracts contain the same molecule the effects of CBN isolate and distillate should be largely the same. Nonetheless, the effects of CBN distillate may be somewhat stronger due to the presence of minor cannabinoids and terpenes. Then again, CBN isolate often contains higher concentrations of total cannabinoids than CBN distillate, potentially equalizing the intensity of the effects provided by the two extracts.

Powder

CBN isolate naturally comes in a powder form, making it easy to infuse into any bulk cannabinoid ingredient—especially water-soluble powder. Even though it’s honey-like in its natural state, it’s just as possible to translate the somewhat wider benefits of CBN distillate into a water-soluble powder extract.

Liquid

Because of its consistency, CBN distillate is naturally ideal for liquid formulations, including both water-soluble liquid and crystal-resistant distillate. Isolates, like CBN isolate, are naturally dry but can be formulated into liquid formulas.

Uses

CBN distillate and isolate share many potential uses, though their applications do not always align. For vape cartridges, CBN distillate’s full-spectrum attributes are often preferred, while isolate suits complex formulations. Both extracts can be formulated with undetectable THC, making CBN isolate and distillate equally desirable under regulations.

Products

Examples of products that are ideal for the utter simplicity CBN isolate include:

1. Capsules

2. Tablets

3. Topicals

Products that are ideal for the rich flavors of CBN distillate, however, include:

1. Vape cartridges

2. Tinctures

3. Gummies

In reality, either type of CBN extract can be included in any of the product types listed above. It all depends on what you’re trying to accomplish and the audience you’re trying to reach. Speak with a qualified cannabinoid white labeller to take a more personalized approach to developing your new CBN product.

Minor cannabinoids

Here’s a category in which there’s a clear and distinct difference between CBN isolate and CBN distillate. While CBN distillate features a rich entourage of minor cannabinoids, CBN isolate does not. Due to its purity, the isolate consists solely of the CBN molecule, rendered down into an almost completely molecularly pure state.

If you want to capture the boost offered by the entourage effect, therefore, you’ll need to go with CBN distillate instead of CBN isolate. CBN distillate contains small concentrations of CBD, CBG, CBC, and other minor cannabinoids, potentially augmenting its effects in a myriad of subtle ways.

Ongoing research

The majority of research into cannabinoids—including research into CBN—focuses on the effects these hemp and cannabis compounds exert when isolated. A growing call is emerging, however, to get to the bottom of the impact of the entourage effect on the benefits of cannabinoids, leading to more research involving cannabinoid distillates. Regardless of which type of extract is used, we’ll learn more about how to use this cannabinoid in products with each new CBN study published.

How do I choose the right CBN extract?

Now that you’re familiar with all the important details regarding CBN distillate and isolate, how do you choose the right type of CBN extract for your exact purposes? Let’s take a look at some of the facts.

In the past, cannabinoid isolates were desirable due to their lack of THC. These days, however, it’s just as possible to remove all detectable traces of THC from distillate, eliminating this advantage.

In the modern hemp market, the main reason you wouldn’t use CBN distillate is to avoid unbalancing a product formulation. If a product already contains a cannabinoid distillate, for instance, increasing the ratio of oils in the formulation could be undesirable. In this case, you could add the benefits of CBN to the product using an isolate extract instead.

The reality is that there are dozens of factors like this to consider when choosing the right cannabinoid extract: all of which are equally important. That’s why it’s best to put your product line together with the expert guidance of a reputable hemp white labeller.

CBN isolate vs. distillate: The bottom line

CBN isolate and distillate may contain the same cannabinoid, but the differences between these two cannabinoid extracts can take an expert touch to properly discern. Choosing the wrong extract could doom an otherwise promising product, but including the right kind of CBN in your product formulation is the first step toward success in the rapidly evolving fringe cannabinoid market.

To unlock the potential benefits of CBN to the fullest for your customers, it’s best to formulate your CBN product line with the help of experienced hemp private labelers. At GVB Biopharma, we exert full vertical integration throughout the production process to ensure the highest possible standards of quality and reliability, and we have the expertise necessary to deliver key insights on product formulation and customization. Contact us to get started.

CBN extract comparison FAQs

1. Is CBN isolate or distillate better?

When comparing CBN isolate to CBN distillate, it would be a mistake to consider one type of extract to be inherently superior to the other. CBN isolate might be the inferior decision in some situations, but there are also plenty of product types in which oily distillates are the wrong choice. Weigh the pros and cons of both CBN isolate and CBN distillate to determine which type of cannabinoid extract is ideal for your particular situation.

2. What is CBN isolate good for?

CBN isolate is ideal for applications in which you want to add a certain amount of CBN to an existing formulation that already contains cannabinoids. This simplified form of extract can also be suitable for use on its own, but shoppers increasingly demand broad-spectrum or full-spectrum extracts in their cannabinoid products. Easy both to handle and to measure for accurate dosing, consider CBN isolate as the reliable workhorse that might nonetheless be a bit less imaginative than other forms of CBN extract.

3. Is CBN distillate water-soluble?

No, CBN distillate is not water-soluble unless otherwise specified. We do, though, offer a water-soluble CBN distillate liquid — contact a client support representative to learn more about this innovative and versatile product type.

4. How much CBN do you need to use?

Due to a general lack of research into this cannabinoid, there is no definitive answer regarding how much CBN each individual should use. Based on the research that has been conducted, though, it appears that there is very little risk associated with using even high concentrations of CBN. While it’s always appropriate to start using any cannabinoid at a low dose, it is recommended to consult with a doctor to determine a dose that is safe for you.

Sources

1. 1. Karniol, I. G., Shirakawa, I., Takahashi, R. N., Knobel, E., & Musty, R. E. (1975). Effects of Δ9-Tetrahydrocannabinol and Cannabinol in Man. Pharmacology, 13(6), 502–512. https://doi.org/10.1159/000136944
2. 2. Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol, and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of Oral Biology, 104, 33–39. https://doi.org/10.1016/j.archoralbio.2019.05.028
3. 3. Weydt, P., Hong, S., Witting, A., Möller, T., Stella, N., & Kliot, M. (2005). Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. Amyotrophic Lateral Sclerosis, 6(3), 182–184. https://doi.org/10.1080/14660820510030149
4. 4. Ferber, S. G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., Shbiro, L., & Weller, A. (2020). The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Current Neuropharmacology, 18(2), 87–96. https://doi.org/10.2174/1570159×17666190903103923

The carboxylic acid CBGa (cannabigerolic acid) plays a critical role in the development of popular cannabinoids during the maturation of the cannabis flower. Recently, CBGa has come into the spotlight due to its usefulness in synthesizing cannabinoids. This cannabinoid precursor became even more famous when CBGa was included in a groundbreaking OSU study into cannabinoids and COVID¹.

In this guide, learn what CBGa is, how it’s different from CBD and CBDa, and everything we know about its benefits so far. With CBGa products now available on the internet, the time has come to demystify this hemp compound and explain its unique properties.

What is CBGa?

Cannabigerolic acid (CBGa)² is a naturally occurring compound found in cannabis and hemp. CBGa is the carboxylic acid precursor to cannabigerol (CBG), which means CBGa turns into CBG when exposed to stimuli that trigger decarboxylation. (the removal of a carbon atom from the CBGa molecule).

UV light, age, and heat can all cause decarboxylation, but some CBGa researchers and entrepreneurs want to catch this carboxylic acid before it settles into its final form. If you expose CBGa to certain natural cannabis enzymes, it will change from the precursor to CBG to the precursor to CBD, THC, or a variety of other cannabinoids.

As a result, CBGa is not only valued for its own benefits. This carboxylic acid is also hotly desired for its ability to turn into other compounds.

CBGa effects

Like CBD, CBDa (CBD’s precursor), and the vast majority of cannabinoids, CBGa is non-intoxicating. People who have used CBGa generally report that it has effects that are similar to those of CBG, which—in turn—are usually reported to be very close to the effects of CBD.

Like CBD, CBGa will not cause any form of intoxication, but it won’t provide exactly the same type of non-intoxicating effect as CBD. Results vary depending on the individual, but CBG is usually reported to be more energizing while CBD is more relaxing.

As with all cannabinoids, the effects of CBGa will vary significantly based on how you use it. Orally ingested, CBGa will deliver long-lasting but relatively mild effects. Inhaled, this cannabinoid precursor will provide much stronger effects that persist for a significantly shorter duration.

CBGa benefits

Even though this hemp substance hasn’t received as much attention as CBD or CBDa, a considerable amount of research has been conducted into the potential benefits CBGa may have to offer. In 2018, for instance, scientists investigated the ability of CBGa to reduce levels of heart-harming enzymes.³ Then, in 2019, researchers took a look at CBGa’s usefulness in combating metabolic disorders⁴.

What did the OSU CBGa study say?

Most recently, researchers at the University of Oregon included CBGa as one of the hemp substances they investigated in relation to COVID-19⁵. The OSU researchers wanted to find out if cannabinoids could neutralize spike proteins using both computer models and chemical assays.

In the end, CBGa and CBDa were among the compounds identified for further study due to both cannabinoids having shown possible activity against the spike protein. As a result, CBGa has suddenly been thrust to the forefront of the conversation surrounding cannabinoids and coronavirus.

Does CBGa fight COVID?

We don’t know enough about CBGa yet to be sure whether or not this compound prevents COVID-19 infection or mitigates the symptoms of this infectious disease. Based on the results of preliminary studies, however, the scientific community would certainly be justified in investigating the potential usefulness of CBGa, CBDa, and other hemp compounds for COVID in more detail.

CBGa vs. CBD

Compared to CBD, CBGa is in a completely different class of compounds and has a significantly different chemical structure. CBGa is a carboxylic acid while CBD is a stabilized cannabinoid, and these two hemp substances also appear to exert different effects.

The effects of CBD are often described as relaxing, and the same goes for CBDa. Users hardly ever report that CBD improves their energy levels, though, but CBGa appears to sometimes have an almost stimulating effect.

CBGa vs. CBG

CBGa and CBG are two sides of the same coin. On the one side, we have CBG, the stabilized form. On the other hand, we have CBGa, its carboxylic acid precursor.

Scientists are starting to discern, however, that CBGa and CBG aren’t exactly alike. For one thing, it’s easy to transform CBGa into a wide variety of different stabilized cannabinoids while the same can’t be said for CBG.

What is CBGa’s decarboxylation temperature?

CBGa converts (decarboxylates) into CBG at 110°C⁷. This means you need to heat CBGa molecules to at least 110 degrees C (230 degrees F) to convert it into CBG. It also means you’ll need to keep your CBGa below this temperature if you plan to use enzymes to transform it into a different carboxylic acid.

What is the best CBGa dosage?

At this point, we don’t know enough about CBGa to provide guidelines for its dosage. The FDA has not even released dosing guidelines for CBD yet, indicating that official standards for CBG and CBGa use are likely many years in the future. If you intend to use this cannabinoid precursor in the interim, just follow the usual dosing procedure you use when trying new hemp compounds for the first time: Start small, and increase your dosage over time as desired.

Does CBGa make you high?

No, just like CBG, CBGa does not have an intoxicating effect. While CBGa might affect your mental state differently than CBD, this cannabinoid precursor’s mildly energizing effets don’t reach the threshold for intoxication. On the contrary, using CBGa might make you feel vaguely upbeat or more prepared to face the day’s challenges.

Is cannabigerolic acid in CBD?

Yes, most CBD products contain trace concentrations of CBGa. Concentrations of CBGa in CBD products, however, rarely exceed 1%, making it difficult to experience the benefits of this cannabinoid by using full-spectrum CBD alone. If you want to enjoy everything CBGa has to offer, ingest this cannabinoid in a product that has been specifically designed to contain high concentrations of CBGa.

How potent is CBGa flower?

Recently, CBG-rich hemp flower has become popular on the internet, with the main active compound in CBG flower being CBGa. The CBG-rich hemp flowers contain high amounts of CBGa because they have not yet undergone decarboxylation thus, the majority of the CBG they contain is still in the form of the carboxylic acid CBGa. At present, the most potent CBG hemp flower contains around 20% total cannabinoids, of which CBGa constitutes a maximum of around 15%.

Where can I buy CBGa products?

You can buy various types of CBGa products online. CBGa products sold online are available on both a retail and wholesale basis. A variety of hemp brands have started offering products containing CBGa in the wake of the OSU COVID study, and there are a few different online CBGa bulk suppliers and white labellers to choose from.

Some examples of popular CBGa product formulations include:

1. CBGa tinctures

2. CBGa capsules

3. CBGa topicals

4. CBGa tablets

5. CBGa gummies

Can I buy CBGa wholesale?

Yes, the cannabinoid precursor CBGa is available online from a variety of different retailers. Quite a few different types of CBGa extract are offered, but remember that it pays to choose your cannabinoid supplier carefully.

Only cannabinoid producers with fully vertically integrated operations and comprehensive multi-stage analytics can produce the type of pure, high-grade CBGa you want to formulate competitive products. Hemp white labellers who go out of their way to acquire every relevant certification should also be preferred.

Is CBGa legal?

Like most cannabinoids aside from THC (delta-9 tetrahydrocannabinol), CBGa generally falls under the definition of “industrial hemp” as per the 2018 Farm Bill⁸. As a result, CBGa products are not considered to be illegal drugs as long as they contain less than 0.3% THC. CBGa products that contain less than this THC threshold are widely shipped and sold across state lines.

Can I sell CBGa products?

Yes, CBGa is generally considered to be an industrial hemp product on the federal, state, county, and municipal level, making obstacles to offering CBGa products online or in your local community rare. As a non-intoxicating cannabinoid with immense potential medicinal benefit, preventing the sale of CBGa products does not appear to be a significant law enforcement objective.

CBGa: Final thoughts

CBGa is just one of a growing roster of new cannabinoids that have the potential to entirely disrupt the hemp industry. While the OSU study has recieved a lot of attention lately, COVID isn’t the only application where CBGa research should be furthered.

There are dozens of ways this cannabinoid precursor might improve human lives, and CBGa will certainly play an important role in cannabis synthesis for years to come. For excellent prices on the world’s best bulk CBGa products, contact one of GVB Biopharma’s business development representatives.

CBGa FAQs

1. How does CBGa make you feel?

According to people who have used this cannabinoid, CBGa seems to have an effect similar to CBG.

Keep in mind, though, that many methods of using CBGa result in converting this cannabinoid into CBG, making products like CBGa vapes essentially CBG products instead. Choose your formulation wisely when crafting a best-selling CBGa product, and always remember that there’s a lot left to learn about both CBG and CBGa.

2. What is considered to be a high CBGa percentage?

In hemp, CBGa can sometimes naturally occur in concentrations of 15% or higher. It is the primary form of CBG found in CBG-rich hemp, and it only oxidizes into CBG after hemp is harvested and processed. CBGa extracts should contain at least 40-50% CBGa with most boasting upwards of 60%.

3. ​​What is CBGa used for?

In the world of consumer hemp products, CBGa is only commonly used in products that are specifically designed to feature this niche cannabinoid. It is sometimes added to CBD or CBG tinctures, for instance, to provide differentiation from competing products.

In the world of cannabinoid science, on the other hand, CBGa is very popular as a raw material used to produce other cannabinoids via enzymatic conversion. Dubbed the “stem cell cannabinoid,” it appears CBGa has an important role to play in the future of cannabinoid research.

4. CBGa vs CBG?

Put side by side, how does CBGa compare to CBG? In the end, it’s a bit hard to compare the two cannabinoids since CBGa naturally converts to CBG at relatively low temperatures. The two compounds are definitely chemically distinct, though, and they appear to affect the body in different ways.

This cannabinoid has a unique chemical structure that seems to have made it the subject of intense interest to researchers, potentially suggesting CBGa has something to offer that CBG does not. Both cannabinoids, though, are non-intoxicating and appear to lack significant side effects.

Sources

1. Oregon State research shows hemp compounds prevent coronavirus from. (2022, January 11). Life at OSU. https://today.oregonstate.edu/news/oregon-state-research-shows-hemp-compounds-prevent-coronavirus-entering-human-cells
2. Havelka, J. (2021, January 25). What is CBGA (Cannabigerolic Acid) & what does this cannabinoid do? Leafly. https://www.leafly.com/news/science-tech/what-is-cbga-cannabigerolic-acid-marijuana-cannabinoid
3. Smeriglio, A., Giofrè, S. V., Galati, E. M., Monforte, M. T., Cicero, N., D’Angelo, V., Grassi, G., & Circosta, C. (2018). Inhibition of aldose reductase activity by chemotypes extracts with high content of cannabidiol or cannabigerol. Fitoterapia, 127, 101–108. https://doi.org/10.1016/j.fitote.2018.02.002
4. D’Aniello, E., Fellous, T., Iannotti, F. A., Gentile, A., Allarà, M., Balestrieri, F., Gray, R., Amodeo, P., Vitale, R. M., & di Marzo, V. (2019). Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach. Biochimica et Biophysica Acta (BBA) – General Subjects, 1863(3), 586–597. https://doi.org/10.1016/j.bbagen.2019.01.002
5. van Breemen, R. B., Muchiri, R. N., Bates, T. A., Weinstein, J. B., Leier, H. C., Farley, S., & Tafesse, F. G. (2022). Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants. Journal of Natural Products, 85(1), 176–184. https://doi.org/10.1021/acs.jnatprod.1c00946
6. Sirikantaramas, S., Taura, F., Tanaka, Y., Ishikawa, Y., Morimoto, S., & Shoyama, Y. (2005). Tetrahydrocannabinolic Acid Synthase, the Enzyme Controlling Marijuana Psychoactivity, is Secreted into the Storage Cavity of the Glandular Trichomes. Plant and Cell Physiology, 46(9), 1578–1582. https://doi.org/10.1093/pcp/pci166
7. Wang, M., Wang, Y. H., Avula, B., Radwan, M. M., Wanas, A. S., van Antwerp, J., Parcher, J. F., ElSohly, M. A., & Khan, I. A. (2016). Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography/Photodiode Array-Mass Spectrometry. Cannabis and Cannabinoid Research, 1(1), 262–271. https://doi.org/10.1089/can.2016.0020
8. Hemp Production and the 2018 Farm Bill. (2019, July 25). U.S. Food and Drug Administration. https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019

The Covid-19 pandemic has placed a tremendous strain on not only the economy but also society in general with businesses and people being affected at crisis levels. All markets felt the economic strain, including those producing hemp-based products. Despite the economic crisis caused by the pandemic, there are a vast number of companies that are benefiting from the introduction of CBD and hemp-based nutraceutical products into the US market. In fact, the demand for nutraceutical hemp seems to be growing exponentially. With the rapidly evolving state of the economy and society in general due to the recent pandemic crisis, it is encouraging to see the rise in demand for hemp nutraceuticals. The medicinal and health benefits of the products themselves drive consumer demand while companies are jumping into the market to bring a diverse array of products to their buyers.¹

Consumers Seeking Nutraceutical Hemp Alternatives for Health

Hemp-based materials are now widely available on the market and consumers contribute to purchasing these products at a progressively steady rate. An estimated 50,000 different products can be derived from industrial hemp, including textiles, food products, building materials, and nutraceuticals. Of these products, nutraceuticals and hemp-based foods have been at the top of consumer purchases.

Hemp-based Food as Medicine

Hemp that is used to improve health and wellness or to treat chronic or acute diseases is known as a nutraceutical. Hemp nutraceuticals can be found in food or supplement form. Food products derived from hemp seeds include hemp milk, hemp seed oil, hulled seeds, cereal, hemp protein powder, and energy bars. People seek these products due to their rich nutritious value as they are high in proteins, antioxidants, and amino acids. 

For example, industrial hemp producers have harvested hemp seeds in great numbers due to recent demand for the nutritious proteins in the health food market. Hemp seeds contain valuable lipids, carbohydrates, and polyunsaturated fatty acids (PUFAs).2 PUFAs are especially abundant in the seeds in a balanced proportion of omega 3, 6, and 9 fatty acids. These dietary fats may contribute to overall health and help to reduce inflammation throughout the body.

Benefits of Hemp Nutraceuticals

Traditional medicine, with its heavy reliance on herbs and nutritious foods as medicine, is used throughout the world to treat illness and disease due to its low cost and high accessibility. With the rising cost of healthcare and the distaste of side effects from pharmaceutical drugs, many people are seeking alternative ways to treat debilitating chronic conditions (such as arthritis and stress disorders) in nutraceutical foods and supplements. Consumers have invested money specifically in hemp nutraceuticals in their pursuit of managing health and chronic disorders to accompany medical treatment advised by their physicians. Numerous studies are currently underway to assess the potential benefits of hemp nutraceuticals in the treatment of a number of neurological, musculoskeletal, and psychological disorders, including:²

 – Neurodegenerative diseases (i.e., multiple sclerosis)
 – Central nervous system diseases (i.ei,  epilepsy. 
 – Anxiety disorders
 – Addiction
 – Chronic pain 
 – Psychotic disorders
 – Sleep disorders

These studies suggest the potential health benefits and therapies of hemp nutraceuticals. Nonetheless, it is important that consumers check with their primary health care providers to make sure that any supplement they are taking (including hemp supplements) do not interact with current medications nor conflict with treatment protocols. 

The Passing of the 2018 Farm Bill Prompts Surge in Consumer Demand for Hemp Nutraceuticals

Hemp farmers celebrated the passing of the Farm Bill in 2018 which removed the prohibition of hemp cultivation and allowed them to begin growing federally legal hemp. This marked a cornerstone in the nutraceutical hemp market, and CBD-based products exploded onto the natural supplement market scene. Consumers prefer these products over pharmaceuticals that often carry unwanted side effects or intoxicating THC-based products. 

The pandemic closely followed the passing of the Farm Bill and millions of people were compelled to self-quarantine. One advantage of the isolation was that many people chose to seek a healthy lifestyle change in nutrition and fitness. Hemp-based food products rich in protein and beneficial fatty acids and amino acids are highly sought after by bodybuilders, athletes, and the general population (especially vegan-based dieters). 

The lifting of the prohibition of hemp 20 years ago has prompted a rise in consumer purchases of hemp-derived products as natural health products and dietary supplements to help manage specific health conditions. Despite the prohibition being lifted, there are still government regulations that encourage stringent control of hemp product sales. The UK is exporting much of the market share of CBD products to the United States. However, Colorado and Kentucky are now contributing to the CBD supply chain and several US companies are forerunners in the development of CBD-based nutraceutical products. 

New Research Estimates $17.4 Billion for CBD Nutraceuticals

Hemp-based CBD is the source of one of the largest new nutraceutical products on the market. Non-psychoactive nutraceutical and nutritional CBD products contain less than .3% THC. This phytocannabinoid has major clinical significance and has been the focus of several hundred clinical trials around the world. One of the major advantages of using CBD nutraceuticals is the lack of side effects when taking the supplement, including the absence of psychoactivity.

North America is emerging as the largest market for CBD nutraceuticals. A report delivered by Grand View Research anticipates a global CBD nutraceuticals market projection of $17.4 billion by the year 2026 with a CAGR (compound annual growth rate) of 18.8% during this forecast period.³ The primary reasons for this emergence are the legalization of Cannabis sativa, the passing of the 2018 Farm Bill, and the increasing numbers of people who are seeking a health-conscious life. The increase in health disorders related to lifestyle and environment has prompted people to seek out hemp nutraceuticals to improve their well-being, especially in regards to mental health and nutrition. Since the Farm Bill passed in 2018, consumer preference has grown substantially for CBD nutraceuticals, with an emphasis in the sales of  CBD edibles and tinctures. 

Technological advances in natural foods and plant medicinal sciences as well as research and development institutions have also contributed to the growth in the hemp nutraceutical market. For instance, the NIH (National Institutes of Health) currently supports a large portfolio of cannabinoid and endocannabinoid systems research studies including cannabinoid therapeutics. In 2022, the NIH will fund an estimated $57 million in therapeutic cannabinoid research alone (with overall estimated funding in cannabinoid research of over $325 million).⁴

What has prompted this growth in the market? There are several players. Consider technological advancement, new product launches, and company acquisitions by leading contributors in the nutraceutical market. Global demand is also increasing for CBD products. Regulations on hemp cultivation and production of hemp-based products have loosened globally and companies are quickly investing in cannabinoid research and development to support the growing market. Tinctures, gel capsules, and salves are highly valued and show the greatest percentage of sales to consumers on a national and global level.⁵ Beyond North America, the Asia-Pacific region has an ever-increasing demand for hemp-based nutraceuticals, especially CBD. The increase in health awareness has also occurred in the nations of Australia, China, and Japan. 

In terms of distribution, CBD nutraceutical companies seek to make their products accessible online and “offline” or in-person sales. Distributors seek to place their products on the shelves of supermarkets, health food stores, specialty retail stores, and pharmacies. Natural health food store chains and nutritional supplement stores are major focal points for hemp nutraceuticals. It is forecast that while tinctures seem to dominate the market, hemp nutraceuticals delivered in gels and capsules are anticipated to be the fastest-growing product type. Hemp nutraceuticals in the form of capsules or tablets are easily swallowed, travel well, and have a longer shelf life than salves or edibles. 

The Future of Hemp Nutraceuticals 

The passing of the Farm Bill in 2018 combined with the rising demand for nutraceutical foods and supplements has bolstered the hemp market and forecasts a profitable future. This boost has been supported by both consumer demand and industry research and development. Several clinical studies have been funded by the NIH and other major medicinal laboratories to test the efficacy of hemp nutraceuticals in the treatment of a number of different disorders, including neurodegenerative diseases and anxiety disorders. Furthermore, consumers choose to purchase non-psychoactive hemp-based food and supplements to improve their health and ease the symptoms of chronic pain and disorders. Hemp foods and nutraceuticals (such as hemp seed and CBD respectively) are largely being developed as a major ingredient in tinctures, capsules, beverages, candies, and baked goods. The combination of consumer demand and promising research points to a growing nutraceutical hemp market for many years to come. 

Nutraceutical cannabinoid FAQs

1. Is CBD a nutraceutical?

As we’ve mentioned, the fact that there is no official definition of the word “nutraceutical” makes it difficult to say whether or not CBD is a nutraceutical substance. Taken completely literally, CBD would not be considered a nutraceutical since it does not come from food.

At the same time, the term is now used much more loosely to refer to any natural health product. So, some people may categorize CBD under this banner.

2. Are hemp pills the same as CBD?

No, it should not be assumed that a product labeled as “hemp pills” will necessarily contain CBD. The hemp plant is very complex and contains a multitude of parts that might be used to make products.

Hemp seeds, for instance, are often used to make dietary supplements even though they do not contain any CBD. To make sure that your hemp pills genuinely contain CBD, look for the acronym “CBD” somewhere on the packaging along with some indication of the number of milligrams of CBD the product contains.

3. Which CBD is FDA-approved?

So far, the only CBD product that has been approved by the FDA is the pharmaceutical medication Epidiolex, and it has only been approved for a very limited number of purposes. You cannot buy Epidiolex without a doctor’s prescription, so none of the CBD available online is technically “FDA-approved.” The federal government is expected to move sometime in 2023, however, to progress the cause of hemp in America with another periodic Farm Bill.

Sources

1. Williamson, E. M.; Liu, X.; Izzo, A. A. Trends in Use, Pharmacology, and Clinical Applications of Emerging Herbal Nutraceuticals. British Journal of Pharmacology 2019, 177(6), 1227-1240. Retrieved from BPS Online Library: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14943

2. Frassinetti, S.; Moccia, E.; Caltavuturo, L.; Gabriele, M.; Longo, V.; Bellani, L.; Giorgi, G.; Giorgetti, L. Nutraceutical Potential of Hemp (Cannabis sativa L.) Seeds and Sprouts. Food Chemistry 2018, 262, 56-66. Retrieved from NIH: https://pubmed.ncbi.nlm.nih.gov/29751921/

3. Grand View Research Writing Staff. CBD Nutraceuticals Market Size, Share & Trends Analysis Report By Product Type (CBD) Tinctures, Capsules & Softgels, CBD Gummies), By Sales Channel, By Region, And Segment Forecasts, 2019 – 2026. 2019. Retrieved from Grand View Research: https://www.grandviewresearch.com/industry-analysis/cbd-nutraceuticals-market

4. National Institutes of Health. Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC). June 25, 2021. Retrieved from NIH: https://report.nih.gov/funding/categorical-spending#/

5. Allied Market Research Writing Staff. CBD Nutraceuticals Market: Global Opportunity Analysis and Industry Forecast, 2020-2030. February 2022 Retrieved From Allied Market Research: https://www.alliedmarketresearch.com/cbd-nutraceuticals-market-A08082

Hemp biomass may not be the most refined hemp product, but it certainly has its uses. As one of the cheapest types of hemp products to cultivate, biomass has quite a few nutraceutical, industrial, and even culinary applications. In this guide, we’ll examine the top 5 most notable uses of hemp biomass, and we’ll answer common hemp biomass questions.

What is hemp biomass?

Hemp biomass is a low-potency combination of outdoor-grown cannabis stalks, leaves, and buds that are usually ground together. High-potency hemp is not usually used to make biomass—instead, this wholesale hemp product is usually composed of mass-produced outdoor hemp and can be valuable for commercial products.

CBD biomass vs. fiber biomass

In the hemp biomass industry, a distinction is often made between CBD biomass and fiber biomass. CBD biomass is hemp biomass that is used for CBD extraction and fiber biomass is used for its fiber content only.

Fiber biomass doesn’t contain enough CBD to be usable for extraction. The buds that fiber biomass hemp plants bear are disregarded, and the whole crop is industrially harvested and processed.

What can you do with hemp biomass? 5 options

CBD and fiber biomass both have a variety of impressive uses. Here are the top 5 ways you can use hemp biomass profitably and efficiently:

1. Can you extract cannabinoids from hemp biomass?

Yes, CBD-rich biomass, commonly called “CBD biomass,” is often used as a source of the non-intoxicating hemp cannabinoid cannabidiol (CBD). Hemp crops considered to be biomass-grade can contain anywhere between 5-15% CBD, which is more than enough to be usable for extraction.

CBD extracted from biomass varies in grade based both on the quality of the plant material and the techniques used by extractors. Some biomass-extracted CBD rivals the quality of the best pure-bud extracts, but CBD extract derived from biomass can also be low-quality if sourced from the wrong supplier. If the starting material isn’t graded high enough to be used for better-quality extracts, CBD biomass can always be used to make CBD isolate, an ultra-purified type of CBD extract consisting solely of the cannabidiol molecule.

2. Is hemp biomass a good source of terpenes?

Depending on its grade, hemp biomass can be a reasonably good source of terpenes even if it doesn’t bear usable quantities of CBD. All hemp flowers naturally contain some concentration of terpenes, but outdoor plants express lower concentrations of these aromatic plant oils, and the terpenes they do express are more prone to damage. As a result, hemp biomass is not an especially popular source of terpenes, but extracting these aromatic oils from biomass is technically possible.

3. Can you use hemp biomass for fiber?

Yes, hemp biomass is an excellent source of fibers that can be used for a variety of purposes including:

– Textiles
– Paper
– Insulation
– Building materials
– & more

Hemp biomass can be used as an excellent source of fiber regardless of its grade. Used as a source of strong, durable fiber for millennia, hemp is unlikely to lose favor as a fiber crop any time soon.

4. Can hemp be used for energy?

Yes, it is possible to derive usable quantities of energy from hemp biomass. Like corn, it’s possible to use the entire hemp plant to make ethanol, and hemp seed oil can be used to make biodiesel¹. At this point, the global capacity to use hemp for energy production is minimal, but since this hardy plant grows well in practically any environment, some clean energy advocates believe hemp could someday become a major source of renewable fuel.

5. Can you make hemp into building materials?

Yes, hemp fiber derived from biomass is used to make a variety of different low-cost and high-durability building materials². Hemp fiber is a great source of insulation, for instance, and it’s possible to combine hemp fiber with simple materials to make hempcrete, a remarkably strong form of plant-based concrete. Production of renewable building materials is a great way to use low-grade hemp biomass that would otherwise be discarded as a waste product.

Hemp biomass FAQs

Now that you know the best ways to use hemp biomass, let’s finish up by answering common hemp biomass questions:

How many ways can you use hemp?

It’s estimated that you can make up to 25,000 different products using the hemp plant³. Hemp flower and cannabinoid extracts are among the most popular hemp products, but some examples of the myriad of additional products you can make with hemp include hemp seed oil, hemp soap, hempcrete, hemp paper, hemp fiber for textiles, and dozens of other useful items.

How much does hemp biomass sell for?

The price of hemp biomass varies depending on its grade. High-quality hemp biomass with high cannabinoid concentrations, for instance, costs considerably more than low-potency biomass only useful for its fiber. Contact GVB Biopharma today⁴ for an accurate bulk hemp biomass quote.

How do you store hemp biomass?

Hemp cultivation experts recommend that you dry hemp biomass prior to storage in a low-humidity, enclosed area⁴ kept at a steady temperature between 68 and 78 degrees. Then, you can store your dried biomass in airtight containers.

Some hemp cultivators choose to grind their dry biomass prior to storage, which makes it easier to store multiple pounds of biomass in large containers like plastic bags. Glass jars are also commonly used for hemp biomass storage—what matters is keeping your biomass cool and dry in a place that’s not exposed to ultraviolet light.

How long can you store hemp biomass?

Wrapped into bales and encased in plastic, hemp biomass can stay good for up to 6 months⁵. Ground-up and processed into pellets, hemp biomass can still be usable after 18 months. You can also store ground-up biomass in a refrigerator to make it last even longer, but don’t expect any hemp biomass to be usable for more than 24 months after its drying date.

Is farming hemp profitable?

Lots of independent farmers started cultivating hemp after the ratification of the 2018 Farm Bill⁶, but as many family farms learned, hemp is usually only profitable when grown in mass-scale environments. Established hemp producers have developed processes that allow them to continue growing high-grade biomass year after year.

What is hemp used for in food?

Only the seeds of the hemp plant are commonly used for culinary purposes. Hemp seeds contain an abundance of protein and nutritious oils, making them an excellent source of essential nutrients. Commonly processed into oil, hemp seeds contain all the amino acids necessary to compose a complete protein.

Less commonly, some people incorporate the leaves or even the stalks of hemp plants into their dishes. Offering less nutritional benefit than hemp seeds, the other parts of the hemp plant are nonetheless edible, offering endless opportunities for creativity.

How do you use hemp leaves?

Since they do not contain high concentrations of cannabinoids or essential nutrients, there aren’t a lot of ways the average person can use hemp leaves. Along with hemp stalks, though, hemp leaves are a great source of fiber of both dietary and industrial varieties.

Due to their delicate structure and high fiber content, hemp leaves are often used to produce higher-end hemp fiber products like hemp fiber. Hemp leaves and stalks are often combined, however, in industrial hemp biomass applications like insulation and other types of building materials.

Where can I buy hemp biomass in bulk?

The best way to buy biomass in bulk is to buy it online from a trusted, vertically-integrated hemp manufacturer⁶. The sheer volume of available hemp biomass has exploded in the wake of the 2018 Farm Bill, but biomass varies significantly in terms of quality and value.

Only established operators have the resources and expertise to consistently produce high-quality hemp biomass. As you select the right online hemp biomass seller to fit your needs, look for a company that comes highly reviewed and has impressive certifications and credentials.

How do I know which type of biomass to buy?

As you choose the right type of hemp biomass for your purposes, remember that CBD-rich biomass is only the right choice if you’re planning to make CBD extracts. For other applications, hemp with negligible concentrations of CBD will do. Contact GVB Biopharma today for assistance in selecting the right type of hemp biomass.

Can you smoke hemp biomass?

No, hemp biomass is not usually “smokable-grade” or suitable for smoking. Instead, it is the coarse material either left behind after hemp production concludes or the lowest-grade outdoor hemp, consisting of small buds interspersed with leaves, stems, or even roots. Smoking biomass is strongly advised against unless otherwise directly specified on the product’s labeling.

How much CBD is in biomass?

Biomass generally contains between 5-15% CBD, depending on the grade. High-grade biomass is the most ideal for extraction, but it understandably costs more than low-grade hemp material due to its high cannabinoid concentrations. Always ask how much CBD is in your biomass before making a purchase. Only biomass with 10%+ CBD concentrations can command a high price in today’s market.

How much is hemp biomass per pound?

The price of hemp biomass per pound varies depending on the grade, the cannabinoid concentration, and a variety of other factors. Expect to pay less than you would for smokable-grade flower or processed hemp extracts. In most cases, biomass is the cheapest type of cannabinoid-rich bulk product you can buy.

What are hemp biomass pellets?

In some cases, hemp biomass is offered in the form of condensed, pressed pellets, which are easier to store and transport. Some cannabinoid producers prefer hemp biomass pellets due to their increased portability, but they are also more expensive due to the labor that goes into their production.

If you decide to purchase hemp biomass pellets, make sure to determine their exact cannabinoid concentration ahead of time. You want to be certain that the increased cost of receiving hemp in pellet form closely correlates with improved concentrations of cannabinoids per volume. Contact a client care representative if you have any further questions regarding available hemp biomass product types.

Sources

1. 1. Prade, T. (2014, January 2). Is industrial hemp the ultimate energy crop? The Conversation. https://theconversation.com/is-industrial-hemp-the-ultimate-energy-crop-20707

2. 2. Not Just a Pipe Dream: Hemp as a Building Material. (2019). Engineering.Com. https://www.engineering.com/story/not-just-a-pipe-dream-hemp-as-a-building-material

3. 3. Yonavjak, L. (2013, August 9). Industrial Hemp: A Win-Win For The Economy And The Environment. Forbes. https://www.forbes.com/sites/ashoka/2013/05/29/industrial-hemp-a-win-win-for-the-economy-and-the-environment/?sh=26efb1c3289b

4. 4. Sandy, E. (2020, November 10). How to Handle Post-Harvest Storage Efficiently and Safely. Hemp Grower. https://www.hempgrower.com/article/hemp-post-harvest-storage-efficiently-and-safely-drying/

5. 5. Drotleff, L. (2021, December 18). Holding on to Hemp. MJBizDaily. https://mjbizdaily.com/hemp-processing-and-storage-techniques-that-are-essential-for-business/

6. 6. Hemp Production and the 2018 Farm Bill. (2019, July 25). U.S. Food and Drug Administration. https://www.fda.gov/news-events/congressional-testimony/hemp-production-and-2018-farm-bill-07252019

Discovered in 1966¹, cannabichromene, or CBC, has been a core component of cannabis research for more than half a century despite being overshadowed by THC and CBD. There’s a lot we still don’t concretely know about CBC, but everything we’ve learned so far indicates this natural cannabinoid is well-worth extensive study. Let’s explore what CBC is, what it does, and the most important facts surrounding this uniquely beneficial cannabinoid.

What is CBC?

Cannabichromene (CBC) is a natural cannabinoid found in Cannabis sativa. Like other cannabinoids, it comes from a parent molecule, an acidic precursor known as cannabichromenic acid (CBCa). CBCa differs from the acid forms of CBD and THC because it does not originate from CBGa, which many mistakenly consider the sole “stem cell” cannabinoid.

CBC appears to be the molecular head of its own little “family” of cannabinoids, which includes CBT (cannabicitran), a rare but fascinating natural cannabinoid² with many unique forms. Perhaps due to its slightly distanced lineage, CBC is known for its unique effects.³ Still generally considered to be non-intoxicating like CBD, the effects of CBC are often described as ‘energizing’.

What is CBC made from?

At this point, breeders have not yet succeeded in cultivating cannabis plants that are naturally high in CBC. Concentrations of this cannabinoid in cannabis flowers rarely exceed 1%, necessitating an alternative source of CBC.

Thankfully, the acidic precursor of CBG, CBGa, can be converted into CBCa relatively easily. Then, it’s simply a matter of decarboxylating CBCa into its final form, CBC, which occurs at temperatures exceeding 250° F.⁴

How is CBC different from CBD?

CBC is different from CBD in terms of chemical structure, pharmacokinetics in the human body, and reported effects. While mimicking CBD in some ways, CBC interacts with a different set of neuroreceptors in the body and brain, and some users report that the effects of CBC are energizing while CBD is usually described as relaxing or even soporific (may cause drowsiness).

It’s worth noting that CBD is also different from CBC in terms of popularity. As a lesser-known cannabinoid, CBC has fewer product options available. However, brands now source reliable CBC extracts, and many CBC products match CBD products in safety and quality.

How CBC Works: Beyond the Basics

Cannabichromene does not directly activate the CB1 or CB2 receptors typically associated with cannabinoids like THC or CBD. Instead, CBC interacts indirectly, particularly through its effects on transient receptor potential channels (TRP channels) and by enhancing the body’s own endocannabinoid system through anandamide uptake inhibition.

This mechanism is significant as anandamide—often called the “bliss molecule”—plays crucial roles in mood regulation, pain relief, and reducing inflammation.

Can you take CBD and CBC together?

Yes, there is no indication that ingesting CBD and CBC together should present any specific dangers. In fact, all the available evidence indicates that combining cannabinoids increases their effectiveness, a phenomenon cannabis scientists have dubbed the “entourage effect.”⁵

Keep in mind, though, that CBD and CBC use the same neuroreceptors for metabolism, so both cannabinoids run the risk of interfering with certain common prescription medications. In general, drugs that come with “grapefruit warnings” are incompatible with cannabinoids. Consumers can consult with physicians if they are concerned about potential CBC drug interactions.

What are the effects of the cannabinoid CBC?

Like CBD, CBC is generally considered non-intoxicating, although its effects differ somewhat from CBD. Scientists have not yet fully established CBC’s exact pharmacokinetics, so it’s unclear why CBC often feels more energizing, whereas CBD tends to be more relaxing.

Whatever the reason behind the differing effects of CBD and CBC, rest assured that neither cannabinoid will cause intoxication. The vast majority of cannabinoids are non-intoxicating, so this similarity between CBD and CBC shouldn’t come as much of a surprise.

The Latest Research on CBC

Anti-Inflammatory and Skin Health

A 2024 study published in the International Journal of Molecular Sciences investigated CBC’s effects on atopic dermatitis (AD) using a mouse model. Topical application of CBC significantly reduced skin lesion severity, ear thickness, and mast cell infiltration. The study also observed a decrease in Th2 cytokines and inflammatory mediators, suggesting that CBC may alleviate AD symptoms by modulating the immune response.

What are the benefits of CBC?

So far, CBC has been investigated for a variety of potential benefits. Based on existing evidence, it’s too soon to make any concrete assumptions regarding the benefits of CBC, but there’s plenty of research to look at as you draw your own conclusions regarding the potential usefulness of this non-intoxicating cannabinoid. Let’s explore the four main areas where researchers have most extensively studied CBC: pain relief, neurological health, skin health, and depression.

Is CBC good for pain?

CBC has been included in studies conducted into the usefulness of cannabinoids for pain.⁶ The results of this research revealed possible analgesic properties in the compound and have encouraged scientists to conduct further research in the pain-relief potential of CBC and other cannabinoids. Expect future research into cannabinoids and pain to increasingly include CBC as a focus.

Is CBC good for your brain?

Scientists have become very interested in the activity of CBC within the human nervous system. Out of all the cannabinoids so far discovered in hemp, CBC appears to exert some of the most activity within the brain and the rest of the nervous system, leading to a 2013 study conducted into the impact of CBC on neural stem cells⁷ along with other related research.

Is CBC good for your skin?

Some research has been conducted into the impact of CBC on acne and other skin conditions.⁸  There is not enough conclusive evidence to understand how CBC affects your skin to draw any conclusions, but interest in CBC-infused topicals is certainly on the rise.

Is CBC good for depression?

Due to its observed neurological activity, scientists have become curious about the usefulness of CBC for depression and related conditions.⁹  Future research may tell us more about the ability of CBC and other cannabinoids to help with common psychological maladies, but there currently is not enough evidence to draw any firm conclusions. 

What is the right dose for CBC?

We don’t know enough about the cannabinoid CBC yet to make any specific recommendations regarding dosing. All the available evidence indicates, however, that CBC is very well-tolerated in human bodies—just like CBD. 

Is CBC legal?

Under the 2018 Farm Bill, CBC is generally classified as a hemp-derived cannabinoid, similar to CBD. Consequently, this non-intoxicating cannabinoid isn’t federally scheduled, and CBC products are readily available for purchase online. Analysts generally contend that CBC is in the same legal category as CBD along with all other natural cannabinoids aside from delta-9 tetrahydrocannabinol (delta 9 THC).

Where can I buy CBC?

The cannabinoid CBC is widely available online in the form of both finished products and isolated extracts. You can buy CBC online in any desired quantity just like any other hemp cannabinoid, and CBC products are offered in both retail and wholesale quantities.

CBC products vary in terms of quality, though, so choose your online supplier with discretion. Fully vertically integrated cannabinoid suppliers with comprehensive certifications and lab reports offer the most reliability and value when it comes to CBC products.

Can I buy CBC in bulk?

Yes, both finished CBC products and CBC extracts are offered in bulk quantities. With demand for CBC rising as consumers learn more about this cannabinoid’s unique benefits, CBC products usually offer excellent sell-through provided that their potential benefits are conveyed effectively. Consult with your bulk cannabinoid supplier for more information on popular CBC product formulations.

What types of wholesale CBC products are there?

The cannabinoid CBC is commonly offered in the form of an isolated extract. CBC isolate is often sold in bulk as-is, but it’s also possible to buy pre-formulated, CBC-infused products such as vapes and topicals. Both oil-based and water-based CBC topicals are offered wholesale online, and you can take your pick between orally ingested products like capsules, tablets, and tinctures. The sky’s the limit when it comes to customized CBC-infused product formulations—contact GVB Biopharma today to learn more.

What are the “big 6” cannabinoids?

The cannabinoids THC, CBD, CBC, CBN, CBG, and THCV are sometimes referred to as the “big 6” due to the amount of research conducted on these compounds alone. However, each of the 100+ cannabinoids discovered in hemp offer unique benefits,and there are many different variants of each big 6 cannabinoid. Examples of additional cannabinoids that are starting to attract more research include CBDV, CBT, and CBL.

CBC FAQs

1. What is cannabichromene good for?

Currently, our understanding of CBC is limited, making it challenging to say what it might be good for. There’s some evidence, however, that cannabichromene might interact with your body and brain’s TRP receptors, which regulate inflammation. So, scientists are keenly researching the potential anti-inflammatory properties of CBC even though we don’t know enough to draw any definitive conclusions.

2. What is the difference between CBG and CBC?

Chemically speaking, CBG and CBC are relatively different. Researchers have recently realized that CBG serves as something like a “stem cell” for the popular and well-known cannabinoids THC and CBD. In the same way, CBC serves as a stem cell for its own group of cannabinoids, which are structurally distinct from their CBG-group counterparts.

Based on the small amount of evidence we’ve accumulated so far, it’s possible that CBC and CBG might be alike in offering effects that are more energizing than those offered by CBD. In terms of benefits and potential medicinal applications, though, it’s too soon to say for either CBG or CBC.

3. What is the difference between CBN and CBC?

While CBN is a derivative of THC that occurs due to oxidative stress, CBC is a unique compound that develops inside budding hemp flowers. It would be theoretically possible, for instance, to breed hemp plants that contain high concentrations of CBC, something that cannot be done with CBN since it only occurs after hemp has been harvested.

4. What is cannabichromene oil?

The term “cannabichromene oil” is sometimes used to refer to concentrated hemp extracts that contain CBC. It can also refer to CBC tinctures in the same way that tinctures with CBD are called “CBD oil.”

Sources

1. Gaoni, Y., & Mechoulam, R. (1966). Cannabichromene, a new active principle in hashish. Chemical Communications (London), 1, 20. https://doi.org/10.1039/c19660000020

2. Radwan, M. M., Chandra, S., Gul, S., & ElSohly, M. A. (2021). Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules, 26(9), 2774. https://doi.org/10.3390/molecules26092774

3. Zagozen, M., Cerenak, A., & Kreft, S. (2021). Cannabigerol and cannabichromene in Cannabis sative L. Acta Pharmaceutica, 71, 355-364. https://hrcak.srce.hr/file/351862

4. Olejar, K. J., & Kinney, C. A. (2021). Evaluation of thermo-chemical conversion temperatures of cannabinoid acids in hemp (Cannabis sativa L.) biomass by pressurized liquid extraction. Journal of Cannabis Research, 3(1). https://doi.org/10.1186/s42238-021-00098-6

5. Ferber, S. G., Namdar, D., Hen-Shoval, D., Eger, G., Koltai, H., Shoval, G., Shbiro, L., & Weller, A. (2020). The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders. Current Neuropharmacology, 18(2), 87–96. https://doi.org/10.2174/1570159×17666190903103923

6. Maione, S., Piscitelli, F., Gatta, L., Vita, D., de Petrocellis, L., Palazzo, E., de Novellis, V., & di Marzo, V. (2011). Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. British Journal of Pharmacology, 162(3), 584–596. https://doi.org/10.1111/j.1476-5381.2010.01063.x

7. Shinjyo, N., & di Marzo, V. (2013). The effect of cannabichromene on adult neural stem/progenitor cells. Neurochemistry International, 63(5), 432–437. https://doi.org/10.1016/j.neuint.2013.08.002

8. Oláh, A., Markovics, A., Szabó-Papp, J., Szabó, P. T., Stott, C., Zouboulis, C. C., & Bíró, T. (2016). Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment. Experimental Dermatology, 25(9), 701–707. https://doi.org/10.1111/exd.13042

9. El-Alfy, A. T., Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., Khan, I., ElSohly, M., & Ross, S. (2010). Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L. Pharmacology Biochemistry and Behavior, 95(4), 434–442. https://doi.org/10.1016/j.pbb.2010.03.004